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Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum ( Didelphis marsupialis) serum
The antibothropic fraction (ABF) already isolated from Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intr...
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| Published in: | Toxicon (Oxford) 2000-06, Vol.38 (6), p.875-880 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c421t-ae62cf0db0ddc38ecac285ebd60ed1c5d4afcb833eb1fde0fa3128b165aca97e3 |
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| cites | cdi_FETCH-LOGICAL-c421t-ae62cf0db0ddc38ecac285ebd60ed1c5d4afcb833eb1fde0fa3128b165aca97e3 |
| container_end_page | 880 |
| container_issue | 6 |
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| container_title | Toxicon (Oxford) |
| container_volume | 38 |
| creator | Rocha, Surza L.G Frutuoso, Valber S Domont, Gilberto B Martins, Marco A Moussatché, Haity Perales, Jonas |
| description | The antibothropic fraction (ABF) already isolated from
Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of
Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i.v. 30 min before venom injection reduced the induced hyperalgesia. This same effect was observed when ABF was intravenously injected at 5 and 15 min after Bjv. Our results show that ABF inhibits also the hyperalgesia induced by Bjv. |
| doi_str_mv | 10.1016/S0041-0101(99)00190-7 |
| format | article |
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Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of
Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i.v. 30 min before venom injection reduced the induced hyperalgesia. This same effect was observed when ABF was intravenously injected at 5 and 15 min after Bjv. Our results show that ABF inhibits also the hyperalgesia induced by Bjv.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/S0041-0101(99)00190-7</identifier><identifier>PMID: 10695972</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animal poisons toxicology. Antivenoms ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antivenins - blood ; Antivenins - therapeutic use ; Azepines - therapeutic use ; Biological and medical sciences ; Bothrops ; Bothrops jararaca ; Bothrops jararaca venom ; Crotalid Venoms - antagonists & inhibitors ; Crotalid Venoms - toxicity ; Dexamethasone - therapeutic use ; Didelphis marsupialis ; Didelphis marsupialis resistance ; hyperalgesia ; Hyperalgesia - chemically induced ; Hyperalgesia - prevention & control ; Hyperalgesic activity ; Indomethacin - therapeutic use ; Medical sciences ; Natural immunity ; Opossums - blood ; Platelet Aggregation Inhibitors - therapeutic use ; Toxicology ; Triazoles - therapeutic use</subject><ispartof>Toxicon (Oxford), 2000-06, Vol.38 (6), p.875-880</ispartof><rights>2000 Elsevier Science Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-ae62cf0db0ddc38ecac285ebd60ed1c5d4afcb833eb1fde0fa3128b165aca97e3</citedby><cites>FETCH-LOGICAL-c421t-ae62cf0db0ddc38ecac285ebd60ed1c5d4afcb833eb1fde0fa3128b165aca97e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1302990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10695972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rocha, Surza L.G</creatorcontrib><creatorcontrib>Frutuoso, Valber S</creatorcontrib><creatorcontrib>Domont, Gilberto B</creatorcontrib><creatorcontrib>Martins, Marco A</creatorcontrib><creatorcontrib>Moussatché, Haity</creatorcontrib><creatorcontrib>Perales, Jonas</creatorcontrib><title>Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum ( Didelphis marsupialis) serum</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>The antibothropic fraction (ABF) already isolated from
Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of
Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i.v. 30 min before venom injection reduced the induced hyperalgesia. This same effect was observed when ABF was intravenously injected at 5 and 15 min after Bjv. Our results show that ABF inhibits also the hyperalgesia induced by Bjv.</description><subject>Animal poisons toxicology. Antivenoms</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Antivenins - blood</subject><subject>Antivenins - therapeutic use</subject><subject>Azepines - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bothrops</subject><subject>Bothrops jararaca</subject><subject>Bothrops jararaca venom</subject><subject>Crotalid Venoms - antagonists & inhibitors</subject><subject>Crotalid Venoms - toxicity</subject><subject>Dexamethasone - therapeutic use</subject><subject>Didelphis marsupialis</subject><subject>Didelphis marsupialis resistance</subject><subject>hyperalgesia</subject><subject>Hyperalgesia - chemically induced</subject><subject>Hyperalgesia - prevention & control</subject><subject>Hyperalgesic activity</subject><subject>Indomethacin - therapeutic use</subject><subject>Medical sciences</subject><subject>Natural immunity</subject><subject>Opossums - blood</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Toxicology</subject><subject>Triazoles - therapeutic use</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1TAQhS0EopfCI4C8QKhdBMbJzY9XFZS_SpVYAGvLsSdkqiQOtnOl-x48ME5zBeyQLXlkf2d8dIax5wJeCxDVm68Ae5FBqi-kvAQQErL6AduJppZZIUp4yHZ_kDP2JIQ7ACgaWT1mZwIqWco637FfN1NPLUVyE3cdjz3y_jij18MPDGS4NpEOFI_r4zsXe-_mwO-0T8tofsDJjbw9cj2lHandiKTr_KpMTSm4QUe06SahbnYhLCO_4O_J4jD3FPiofVhm0gOFSx7QL-NT9qjTQ8Bnp_Ocff_44dv15-z2y6eb67e3mdnnImYaq9x0YFuw1hQNGm3ypsTWVoBWmNLudWfapiiwFZ1F6HQh8qYVVZm8yxqLc_Zq6zt793PBENVIweAw6AndEpSoS2jqqk5guYHGJ_8eOzV7Sr6PSoBax6Hux6HWrJWU6n4catW9OH2wtCPaf1Rb_gl4eQJ0MHpIqU2Gwl-ugFxKSNjVhmFK40DoVTCEk0FLHk1U1tF_nPwGtUir2A</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Rocha, Surza L.G</creator><creator>Frutuoso, Valber S</creator><creator>Domont, Gilberto B</creator><creator>Martins, Marco A</creator><creator>Moussatché, Haity</creator><creator>Perales, Jonas</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20000601</creationdate><title>Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum ( Didelphis marsupialis) serum</title><author>Rocha, Surza L.G ; Frutuoso, Valber S ; Domont, Gilberto B ; Martins, Marco A ; Moussatché, Haity ; Perales, Jonas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-ae62cf0db0ddc38ecac285ebd60ed1c5d4afcb833eb1fde0fa3128b165aca97e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animal poisons toxicology. Antivenoms</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Antivenins - blood</topic><topic>Antivenins - therapeutic use</topic><topic>Azepines - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bothrops</topic><topic>Bothrops jararaca</topic><topic>Bothrops jararaca venom</topic><topic>Crotalid Venoms - antagonists & inhibitors</topic><topic>Crotalid Venoms - toxicity</topic><topic>Dexamethasone - therapeutic use</topic><topic>Didelphis marsupialis</topic><topic>Didelphis marsupialis resistance</topic><topic>hyperalgesia</topic><topic>Hyperalgesia - chemically induced</topic><topic>Hyperalgesia - prevention & control</topic><topic>Hyperalgesic activity</topic><topic>Indomethacin - therapeutic use</topic><topic>Medical sciences</topic><topic>Natural immunity</topic><topic>Opossums - blood</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Toxicology</topic><topic>Triazoles - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rocha, Surza L.G</creatorcontrib><creatorcontrib>Frutuoso, Valber S</creatorcontrib><creatorcontrib>Domont, Gilberto B</creatorcontrib><creatorcontrib>Martins, Marco A</creatorcontrib><creatorcontrib>Moussatché, Haity</creatorcontrib><creatorcontrib>Perales, Jonas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rocha, Surza L.G</au><au>Frutuoso, Valber S</au><au>Domont, Gilberto B</au><au>Martins, Marco A</au><au>Moussatché, Haity</au><au>Perales, Jonas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum ( Didelphis marsupialis) serum</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>38</volume><issue>6</issue><spage>875</spage><epage>880</epage><pages>875-880</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>The antibothropic fraction (ABF) already isolated from
Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of
Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i.v. 30 min before venom injection reduced the induced hyperalgesia. This same effect was observed when ABF was intravenously injected at 5 and 15 min after Bjv. Our results show that ABF inhibits also the hyperalgesia induced by Bjv.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10695972</pmid><doi>10.1016/S0041-0101(99)00190-7</doi><tpages>6</tpages></addata></record> |
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| ispartof | Toxicon (Oxford), 2000-06, Vol.38 (6), p.875-880 |
| issn | 0041-0101 1879-3150 |
| language | eng |
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| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | Animal poisons toxicology. Antivenoms Animals Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antivenins - blood Antivenins - therapeutic use Azepines - therapeutic use Biological and medical sciences Bothrops Bothrops jararaca Bothrops jararaca venom Crotalid Venoms - antagonists & inhibitors Crotalid Venoms - toxicity Dexamethasone - therapeutic use Didelphis marsupialis Didelphis marsupialis resistance hyperalgesia Hyperalgesia - chemically induced Hyperalgesia - prevention & control Hyperalgesic activity Indomethacin - therapeutic use Medical sciences Natural immunity Opossums - blood Platelet Aggregation Inhibitors - therapeutic use Toxicology Triazoles - therapeutic use |
| title | Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum ( Didelphis marsupialis) serum |
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