Evaluation of the Developmental Toxicity of Amlodipine Besylate in Mice

Amlodipine besylate, a dihydropyridine calcium antagonist, was evaluated for its potential to cause embryonal fetal toxicity and teratogenicity in pregnant mice. Amlodipine was administered in drinking fluid at dose levels of 0.2, 0.8 and 1.6mg/kg body weight on days 1 through 21 of gestation. Litte...

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Bibliographic Details
Published in:Journal of Health Science 2000/02/01, Vol.46(1), pp.42-45
Main Authors: Orish, Ebere, Kingsley, Chisorom, Onyenmechi, Johnson, Ejeatuluchukwu, Obi, Ndidi, Ilondu
Format: Article
Language:English
Subjects:
amlodipine besylate
maternal toxicity
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Summary:Amlodipine besylate, a dihydropyridine calcium antagonist, was evaluated for its potential to cause embryonal fetal toxicity and teratogenicity in pregnant mice. Amlodipine was administered in drinking fluid at dose levels of 0.2, 0.8 and 1.6mg/kg body weight on days 1 through 21 of gestation. Litters were examined on gestational day 21. There were significant (p
ISSN:1344-9702
1347-5207
DOI:10.1248/jhs.46.42