Phenytoin and electric shock-induced apoptosis in rat peripheral blood lymphocytes

The apoptotic index (AI) of peripheral blood lymphocytes (PBL) and plasma corticosterone (CS) levels were determined in Wistar rats treated with phenytoin (PHT) at therapeutic and toxic doses (100 or 200 mg/kg/day, respectively, over a period of 7 days) and stressed by bifrontal electric shock (60 H...

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Bibliographic Details
Published in:International journal of immunopharmacology 2000-02, Vol.22 (2), p.143-150
Main Authors: Villaseñor-Garcı́a, M.M, Puebla-Pérez, A.M, Sandoval-Ramı́rez, L, Lozoya, X
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - toxicity
Anticonvulsants. Antiepileptics. Antiparkinson agents
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Chromatography, High Pressure Liquid
Corticosterone
Corticosterone - blood
Electroshock
Hypothalamic–pituitary–adrenals axis
Lymphocytes - drug effects
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Phenytoin
Phenytoin - blood
Phenytoin - toxicity
Rats
Rats, Wistar
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Summary:The apoptotic index (AI) of peripheral blood lymphocytes (PBL) and plasma corticosterone (CS) levels were determined in Wistar rats treated with phenytoin (PHT) at therapeutic and toxic doses (100 or 200 mg/kg/day, respectively, over a period of 7 days) and stressed by bifrontal electric shock (60 Hz/40 mA/0.2 seg). The values of CS and AI were found to be significantly higher in rats submitted to electric shock (ES) and in rats treated with therapeutic and toxic doses of PHT plus ES, than in rats treated only with PHT ( P
ISSN:0192-0561
1879-3495
DOI:10.1016/S0192-0561(99)00069-7