Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing

This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates...

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Bibliographic Details
Published in:Journal of controlled release 2015-12, Vol.220 (Pt B), p.624-630
Main Authors: Kang, Youngnam, Kim, Jihoon, Lee, Yeong Mi, Im, Sooseok, Park, Hansoo, Kim, Won Jong
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Azo Compounds - administration & dosage
Azo Compounds - chemical synthesis
Chemistry, Pharmaceutical
Collagen - metabolism
Mice
N-diazeniumdiolate
Neovascularization, Physiologic - drug effects
Nitric oxide
Nitric Oxide - metabolism
Nitric Oxide Donors - administration & dosage
Nitric Oxide Donors - chemical synthesis
Ointment
Ointments
Poloxamer - administration & dosage
Poloxamer - analogs & derivatives
Poloxamer - chemical synthesis
Polyethylene Glycols - chemistry
Polyethyleneimine - administration & dosage
Polyethyleneimine - analogs & derivatives
Polyethyleneimine - chemical synthesis
Re-Epithelialization - drug effects
Skin - blood supply
Skin - drug effects
Skin - metabolism
Skin - pathology
Time Factors
Wound healing
Wound Healing - drug effects
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Summary:This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2015.08.057