Age-adjusted glycated albumin accurately reflects blood glucose in patients with neonatal diabetes mellitus: comparison with calculated glycated albumin determined by past blood glucose concentrations

• Published in: Annals of clinical biochemistry 2016-01, Vol.53 (1), p.117-123
• Main Authors: Suzuki, Shigeru, Furuya, Akiko, Oshima, Miho, Amamiya, Satoshi, Nakao, Atsushi, Wada, Keiko, Okuhara, Koji, Hayano, Satoshi, Imamoto, Aya, Matsuo, Kumihiro, Tanahashi, Yusuke, Azuma, Hiroshi, Koga, Masafumi
• Format: Article
• Language: English
• Subjects: Adult; Aging - blood; Blood Chemical Analysis - methods; Blood Glucose - analysis; Diabetes Mellitus - blood; Female; Humans; Infant; Infant, Newborn; Male; Serum Albumin - analysis
• ISSN: 0004-5632; 1758-1001
• DOI: 10.1177/0004563215589382

Background Glycated albumin is a useful glycaemic control indicator for neonatal diabetes mellitus. However, glycated albumin concentrations in infants are lower than those in adults and increase in an age-dependent manner. Based on our investigation of non-diabetic subjects, we proposed the possibility that the reference range for adults may be used regardless of age, provided that age-adjusted glycated albumin is employed. In the present study, we evaluate the usefulness of age-adjusted glycated albumin in neonatal diabetes mellitus patients. Methods Six neonatal diabetes mellitus patients (four patients with permanent neonatal diabetes mellitus and two patients with transient neonatal diabetes mellitus) were included. Measured glycated albumin or age-adjusted glycated albumin was compared to calculated glycated albumin, which was determined using calculation formulae we had reported based on past blood glucose over the 50 days before measurement of glycated albumin. Results Measured glycated albumin was significantly lower than calculated glycated albumin (20.5 ± 4.9% versus 28.2 ± 6.1%; p