Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats

Highlights • SE results in neuronal- and astroglial-ER stress in the rat hippocampus. • Up-regulated PDI expression is associated with astroglial apoptosis. • Increased CNX expression is detected in clasmatodendritic astrocytes. • SE-induced ER stress is relevant to regional-specific astroglial loss...

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Bibliographic Details
Published in:Neuroscience 2015-10, Vol.307, p.199-214
Main Authors: Ko, A.-R, Kim, J.Y, Hyun, H.-W, Kim, J.-E
Format: Article
Language:English
Subjects:
Animals
Apoptosis Inducing Factor - metabolism
Astrocytes - metabolism
calnexin
Calnexin - metabolism
Disease Models, Animal
Endoplasmic Reticulum Stress - physiology
GRP78
GRP94
Hippocampus - pathology
HSP70 Heat-Shock Proteins - metabolism
In Situ Nick-End Labeling
Lithium Chloride - toxicity
Male
Membrane Proteins - metabolism
Nerve Tissue Proteins - metabolism
Neurology
Pilocarpine
protein disulfide isomerase
Rats
Rats, Sprague-Dawley
status epilepticus
Status Epilepticus - chemically induced
Status Epilepticus - pathology
Time Factors
Transcription Factor CHOP - metabolism
Up-Regulation - drug effects
Up-Regulation - physiology
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Summary:Highlights • SE results in neuronal- and astroglial-ER stress in the rat hippocampus. • Up-regulated PDI expression is associated with astroglial apoptosis. • Increased CNX expression is detected in clasmatodendritic astrocytes. • SE-induced ER stress is relevant to regional-specific astroglial loss.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.08.061