Rationalizing thymic selection for functional T-cells: A commentary

•Tregs are T-suppressors selected to be anti-nonself.•Tregs control the effector response not tolerance.•Tregs are essential to minimize bystander immunopathology. What are the minimum specificity requirements of a thymic selective process that establishes (1) restrictive recognition of peptide, (2)...

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Bibliographic Details
Published in:Cellular immunology 2015-11, Vol.298 (1-2), p.83-87
Main Author: Cohn, Melvin
Format: Article
Language:English
Subjects:
Cytotoxic T-cells
Humans
Lymphocyte Activation - immunology
Peripheralized T-cells
Receptors, Antigen, T-Cell - immunology
Self Tolerance - immunology
T-helpers
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - immunology
T-suppressors
Thymic negative selection
Thymic positive selection
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Summary:•Tregs are T-suppressors selected to be anti-nonself.•Tregs control the effector response not tolerance.•Tregs are essential to minimize bystander immunopathology. What are the minimum specificity requirements of a thymic selective process that establishes (1) restrictive recognition of peptide, (2) the Self (S)–Nonself (NS) discrimination, and (3) the categories of effector function? Given an answer to that question, how well does it fit with the observed selective processes in thymus where T-cells are generated? Any discrepancies between the two must be rationalized. The goal of this essay is to attempt just that.
ISSN:0008-8749
1090-2163
DOI:10.1016/j.cellimm.2015.09.008