Molecular diagnostics in paediatric glial tumours

Summary Glial tumours in children have distinct patterns of epigenetic alteration, chromosomal structure, and gene and protein expression that differentiate them from their histological counterparts in adults. Understanding paediatric gliomas at the molecular level provides important prognostic and...

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Bibliographic Details
Published in:The lancet oncology 2013, Vol.14 (1), p.e19-e27
Main Authors: Kim, Joon-Hyung, BS, Huse, Jason T, MD, Huang, Yujie, PhD, Lyden, David, MD, Greenfield, Jeffrey P, Dr
Format: Article
Language:English
Subjects:
Adult
Autopsies
Biopsy
Brain cancer
Child
Glioma - classification
Glioma - diagnosis
Glioma - metabolism
Glioma - pathology
Hematology, Oncology and Palliative Medicine
Histology
Humans
Mutation
Pathology, Molecular
Pediatrics
Prognosis
Signal Transduction
Tumors
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Summary:Summary Glial tumours in children have distinct patterns of epigenetic alteration, chromosomal structure, and gene and protein expression that differentiate them from their histological counterparts in adults. Understanding paediatric gliomas at the molecular level provides important prognostic and therapeutic insights, such as which genetic alterations confer a favourable response to adjuvant therapy, or which signalling pathways might be amenable to specific molecularly targeted agents. For clinicians, the ultimate goal is to individualise therapeutic regimens on the basis of the molecular fingerprint of a particular tumour and the prognosis conferred by this profile. In this Review, we examine a series of studies of molecular and genomic analysis of glial tumours in children, and discuss the many clinical insights that these molecular features provide.
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(12)70577-6