Inflammatory and metabolic markers and short-time outcome in patients with acute ischemic stroke in relation to TOAST subtypes

The aim of this study was to evaluate the association between inflammatory and metabolic markers and short-time outcome with acute ischemic stroke subtypes. A total of 121 patients was classified according to TOAST criteria, such as large artery atherosclerosis (LAAS), lacunar infarct (LAC), cardioe...

Full description

Saved in:
Bibliographic Details
Published in:Metabolic brain disease 2015-12, Vol.30 (6), p.1417-1428
Main Authors: Lehmann, Marcio Francisco, Kallaur, Ana Paula, Oliveira, Sayonara Rangel, Alfieri, Daniela Frizon, Delongui, Franciele, de Sousa Parreira, Johnathan, de Araújo, Maria Caroline Martins, Rossato, Carolina, de Almeida, Jéssica Tavares, Pelegrino, Larissa Moliterno, Bragato, Erick Frank, Lehmann, Ana Lucia Cruz Fürstenberger, Morimoto, Helena Kaminami, Lozovoy, Marcell Alysson Batisti, Simão, Andrea Name Colado, Kaimen-Maciel, Damácio Ramon, Reiche, Edna Maria Vissoci
Format: Article
Language:English
Subjects:
Adult
Aged
Anthropometry
Biochemistry
Biomarkers
Biomedical and Life Sciences
Biomedicine
Brain Ischemia - classification
Brain Ischemia - metabolism
Brain Ischemia - pathology
Brazil
C-Reactive Protein - analysis
Case-Control Studies
Cerebral Infarction - pathology
Female
Humans
Inflammation - metabolism
Inflammation - pathology
Interleukin-6 - blood
Male
Matrix Metalloproteinase 9 - blood
Metabolic Diseases
Middle Aged
Neurology
Neurosciences
Oncology
Original Article
Socioeconomic Factors
Stroke - classification
Stroke - metabolism
Stroke - pathology
Treatment Outcome
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to evaluate the association between inflammatory and metabolic markers and short-time outcome with acute ischemic stroke subtypes. A total of 121 patients was classified according to TOAST criteria, such as large artery atherosclerosis (LAAS), lacunar infarct (LAC), cardioembolic infarct (CEI), other determined etiology (ODE), and undetermined etiology (UDE). The functional impairment was evaluated within the first eight hours of stroke and the outcome after three-month follow-up using the modified Rankin Scale. Blood samples were obtained up to 24 h of stroke. Compared with 96 controls, patients with LAAS, CEI, and LAC subtypes showed higher levels of white blood cells, high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), metalloproteinase 9 (MMP-9), glucose, and iron ( p  
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-015-9731-8