United States trends in thrombolysis for older adults with acute ischemic stroke

Highlights • We investigated trends in thrombolysis use in older adults for ischemic stroke. • Data from the Nationwide Inpatient Sample (NIS) from 2005 to 2010 were queried. • Thrombolysis increased 3-fold the largest increase among the oldest patients (≥85). • No thrombolysis-related change in ICH...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2015-12, Vol.139, p.16-23
Main Authors: George, Benjamin P, Asemota, Anthony O, Dorsey, E. Ray, Haider, Adil H, Smart, Blair J, Urrutia, Victor C, Schneider, Eric B
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Brain Ischemia - complications
Brain Ischemia - drug therapy
Brain Ischemia - mortality
Cerebral Hemorrhage - epidemiology
Cerebral Hemorrhage - mortality
Databases, Factual
Epidemiology
Female
Fibrinolytic Agents - therapeutic use
Heart attacks
Hospital Mortality
Hospitalization
Hospitals - statistics & numerical data
Humans
Ischemic stroke
Male
Mortality
Neurology
Neurosurgery
Odds Ratio
Older people
Retrospective Studies
Stroke
Stroke - drug therapy
Stroke - etiology
Stroke - mortality
Thrombolysis
Thrombolytic Therapy - trends
Tissue plasminogen activator
Tissue Plasminogen Activator - therapeutic use
tPA
Treatment Outcome
Trends
United States - epidemiology
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Summary:Highlights • We investigated trends in thrombolysis use in older adults for ischemic stroke. • Data from the Nationwide Inpatient Sample (NIS) from 2005 to 2010 were queried. • Thrombolysis increased 3-fold the largest increase among the oldest patients (≥85). • No thrombolysis-related change in ICH or in-hospital mortality over time. • Thrombolysis rate increase primarily limited to urban/high volume hospitals.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2015.08.031