Comparative Study of Serum Copper, Iron, Magnesium, and Zinc in Type 2 Diabetes-Associated Proteinuria

Trace element (TE) disturbances are well noted in type 2 diabetes mellitus (T2DM) and its associated complications. In present study, the effect of proteinuria on serum copper (Cu), iron (Fe), magnesium (Mg), and zinc (Zn) in T2DM patients with and without proteinuria was seen. Total subjects were a...

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Bibliographic Details
Published in:Biological trace element research 2015-12, Vol.168 (2), p.321-329
Main Authors: Khan, Farah Aziz, Al Jameil, Noura, Arjumand, Sadia, Khan, Mohammad Fareed, Tabassum, Hajera, Alenzi, Naif, Hijazy, Sereen, Alenzi, Samyah, Subaie, Sahar, Fatima, Sabiha
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
albumins
Albumins - analysis
Albuminuria - blood
Analysis of Variance
Biochemistry
Biomedical and Life Sciences
Biotechnology
blood serum
Comparative studies
Copper
Copper - blood
creatinine
Diabetes
Diabetes Complications - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Disease Progression
Female
Humans
Iron
Iron - blood
Kidney diseases
Life Sciences
Magnesium
Magnesium - blood
Male
Middle Aged
Nephelometry and Turbidimetry
noninsulin-dependent diabetes mellitus
Nutrition
Oncology
patients
Proteins
proteinuria
Proteinuria - blood
Proteinuria - complications
Statistical analysis
t-test
Trace elements
Trace Elements - blood
Urine
Variance analysis
Zinc
Zinc - blood
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Summary:Trace element (TE) disturbances are well noted in type 2 diabetes mellitus (T2DM) and its associated complications. In present study, the effect of proteinuria on serum copper (Cu), iron (Fe), magnesium (Mg), and zinc (Zn) in T2DM patients with and without proteinuria was seen. Total subjects were aged between 30 and 90 years; 73 had proteinuria, 76 had T2DM with proteinuria, 76 had T2DM, and 75 were controls. Serum Cu(II), Fe(III), Mg(II), and Zn(II) were assayed by inductively coupled plasma optical emission spectrometer (ICP-OES). Urinary albumin estimation was performed by turbidimetric method. Other biochemical parameters were analyzed by ROCHE Module COBAS 6000 analyzer. Statistical analysis was performed using analysis of variance (ANOVA) at P 
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-015-0379-3