Comparative Study of Serum Copper, Iron, Magnesium, and Zinc in Type 2 Diabetes-Associated Proteinuria

Trace element (TE) disturbances are well noted in type 2 diabetes mellitus (T2DM) and its associated complications. In present study, the effect of proteinuria on serum copper (Cu), iron (Fe), magnesium (Mg), and zinc (Zn) in T2DM patients with and without proteinuria was seen. Total subjects were a...

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Published in:Biological trace element research 2015-12, Vol.168 (2), p.321-329
Main Authors: Khan, Farah Aziz, Al Jameil, Noura, Arjumand, Sadia, Khan, Mohammad Fareed, Tabassum, Hajera, Alenzi, Naif, Hijazy, Sereen, Alenzi, Samyah, Subaie, Sahar, Fatima, Sabiha
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
albumins
Albumins - analysis
Albuminuria - blood
Analysis of Variance
Biochemistry
Biomedical and Life Sciences
Biotechnology
blood serum
Comparative studies
Copper
Copper - blood
creatinine
Diabetes
Diabetes Complications - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Disease Progression
Female
Humans
Iron
Iron - blood
Kidney diseases
Life Sciences
Magnesium
Magnesium - blood
Male
Middle Aged
Nephelometry and Turbidimetry
noninsulin-dependent diabetes mellitus
Nutrition
Oncology
patients
Proteins
proteinuria
Proteinuria - blood
Proteinuria - complications
Statistical analysis
t-test
Trace elements
Trace Elements - blood
Urine
Variance analysis
Zinc
Zinc - blood
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cited_by cdi_FETCH-LOGICAL-c499t-aa19aec9eacd31ac2380694439b52c76ab75a730032924c8299663491b1ae3da3
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container_start_page 321
container_title Biological trace element research
container_volume 168
creator Khan, Farah Aziz
Al Jameil, Noura
Arjumand, Sadia
Khan, Mohammad Fareed
Tabassum, Hajera
Alenzi, Naif
Hijazy, Sereen
Alenzi, Samyah
Subaie, Sahar
Fatima, Sabiha
description Trace element (TE) disturbances are well noted in type 2 diabetes mellitus (T2DM) and its associated complications. In present study, the effect of proteinuria on serum copper (Cu), iron (Fe), magnesium (Mg), and zinc (Zn) in T2DM patients with and without proteinuria was seen. Total subjects were aged between 30 and 90 years; 73 had proteinuria, 76 had T2DM with proteinuria, 76 had T2DM, and 75 were controls. Serum Cu(II), Fe(III), Mg(II), and Zn(II) were assayed by inductively coupled plasma optical emission spectrometer (ICP-OES). Urinary albumin estimation was performed by turbidimetric method. Other biochemical parameters were analyzed by ROCHE Module COBAS 6000 analyzer. Statistical analysis was performed using analysis of variance (ANOVA) at P 
doi_str_mv 10.1007/s12011-015-0379-3
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In present study, the effect of proteinuria on serum copper (Cu), iron (Fe), magnesium (Mg), and zinc (Zn) in T2DM patients with and without proteinuria was seen. Total subjects were aged between 30 and 90 years; 73 had proteinuria, 76 had T2DM with proteinuria, 76 had T2DM, and 75 were controls. Serum Cu(II), Fe(III), Mg(II), and Zn(II) were assayed by inductively coupled plasma optical emission spectrometer (ICP-OES). Urinary albumin estimation was performed by turbidimetric method. Other biochemical parameters were analyzed by ROCHE Module COBAS 6000 analyzer. Statistical analysis was performed using analysis of variance (ANOVA) at P < 0.0001 followed by t test. Pearson correlation was applied to estimate the effect of proteinuria on TE. Serum Cu(II) level was increased in T2DM patients with proteinuria while Fe(III) was found elevated in T2DM (P < 0.0001) compared to control groups. Zn(II) and Mg(II) were significantly low in proteinuria, T2DM with proteinuria, and T2DM (P < 0.0001) compare to controls. Serum Cu(II) showed strong positive association with albumin creatinine ratio (ACR) in T2DM with proteinuria group and T2DM group (P < 0.01). Fe(III) was positively and Zn(II) was negatively associated with ACR at P < 0.10, in T2DM with proteinuria group. Mg(II) was negatively linked with ACR P < 0.01 in proteinuria, T2DM with proteinuria, and T2DM group. 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In present study, the effect of proteinuria on serum copper (Cu), iron (Fe), magnesium (Mg), and zinc (Zn) in T2DM patients with and without proteinuria was seen. Total subjects were aged between 30 and 90 years; 73 had proteinuria, 76 had T2DM with proteinuria, 76 had T2DM, and 75 were controls. Serum Cu(II), Fe(III), Mg(II), and Zn(II) were assayed by inductively coupled plasma optical emission spectrometer (ICP-OES). Urinary albumin estimation was performed by turbidimetric method. Other biochemical parameters were analyzed by ROCHE Module COBAS 6000 analyzer. Statistical analysis was performed using analysis of variance (ANOVA) at P < 0.0001 followed by t test. Pearson correlation was applied to estimate the effect of proteinuria on TE. Serum Cu(II) level was increased in T2DM patients with proteinuria while Fe(III) was found elevated in T2DM (P < 0.0001) compared to control groups. 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In present study, the effect of proteinuria on serum copper (Cu), iron (Fe), magnesium (Mg), and zinc (Zn) in T2DM patients with and without proteinuria was seen. Total subjects were aged between 30 and 90 years; 73 had proteinuria, 76 had T2DM with proteinuria, 76 had T2DM, and 75 were controls. Serum Cu(II), Fe(III), Mg(II), and Zn(II) were assayed by inductively coupled plasma optical emission spectrometer (ICP-OES). Urinary albumin estimation was performed by turbidimetric method. Other biochemical parameters were analyzed by ROCHE Module COBAS 6000 analyzer. Statistical analysis was performed using analysis of variance (ANOVA) at P < 0.0001 followed by t test. Pearson correlation was applied to estimate the effect of proteinuria on TE. Serum Cu(II) level was increased in T2DM patients with proteinuria while Fe(III) was found elevated in T2DM (P < 0.0001) compared to control groups. Zn(II) and Mg(II) were significantly low in proteinuria, T2DM with proteinuria, and T2DM (P < 0.0001) compare to controls. Serum Cu(II) showed strong positive association with albumin creatinine ratio (ACR) in T2DM with proteinuria group and T2DM group (P < 0.01). Fe(III) was positively and Zn(II) was negatively associated with ACR at P < 0.10, in T2DM with proteinuria group. Mg(II) was negatively linked with ACR P < 0.01 in proteinuria, T2DM with proteinuria, and T2DM group. TE were observed more disturbed in T2DM with proteinuria group, thus considered to be the part of T2DM routine checkup and restricts the disease towards its progression.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>26024734</pmid><doi>10.1007/s12011-015-0379-3</doi><tpages>9</tpages></addata></record>
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subjects Adult
Aged
Aged, 80 and over
albumins
Albumins - analysis
Albuminuria - blood
Analysis of Variance
Biochemistry
Biomedical and Life Sciences
Biotechnology
blood serum
Comparative studies
Copper
Copper - blood
creatinine
Diabetes
Diabetes Complications - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Disease Progression
Female
Humans
Iron
Iron - blood
Kidney diseases
Life Sciences
Magnesium
Magnesium - blood
Male
Middle Aged
Nephelometry and Turbidimetry
noninsulin-dependent diabetes mellitus
Nutrition
Oncology
patients
Proteins
proteinuria
Proteinuria - blood
Proteinuria - complications
Statistical analysis
t-test
Trace elements
Trace Elements - blood
Urine
Variance analysis
Zinc
Zinc - blood
title Comparative Study of Serum Copper, Iron, Magnesium, and Zinc in Type 2 Diabetes-Associated Proteinuria
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