Complete genomic characterization and genetic diversity of four European genotype porcine reproductive and respiratory syndrome virus isolates from China in 2011

Porcine reproductive and respiratory syndrome (PRRS) is an emerging disease that has caused serious economic losses to the swine industry worldwide. In 2011, a nation-wide surveillance program investigated the prevalence of PRRS viruses (PRRSV) in Chinese breeding swine farms, and four European geno...

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Bibliographic Details
Published in:Virus genes 2015-12, Vol.51 (3), p.375-384
Main Authors: Zhou, Zhi, Liu, Qi, Hu, Dongmei, Zhang, Qian, Han, Tao, Ma, Ying, Gu, Xiaoxue, Zhai, Xinyan, Tian, Kegong
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biomedical and Life Sciences
Biomedicine
China - epidemiology
Evolution, Molecular
Genetic Variation
Genome, Viral
Medical Microbiology
Molecular Sequence Data
Phylogeny
Plant Sciences
Porcine Reproductive and Respiratory Syndrome - blood
Porcine Reproductive and Respiratory Syndrome - epidemiology
Porcine Reproductive and Respiratory Syndrome - virology
Porcine respiratory and reproductive syndrome virus
Porcine respiratory and reproductive syndrome virus - genetics
Porcine respiratory and reproductive syndrome virus - isolation & purification
RNA, Viral - genetics
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Swine
Viral Proteins - genetics
Virology
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Summary:Porcine reproductive and respiratory syndrome (PRRS) is an emerging disease that has caused serious economic losses to the swine industry worldwide. In 2011, a nation-wide surveillance program investigated the prevalence of PRRS viruses (PRRSV) in Chinese breeding swine farms, and four European genotype PRRSV (PRRSV-Type 1) were successfully isolated. To explore the genetic diversity of PRRSV-Type 1 in China, these 4 viral strains were subjected to genome sequencing and analysis. The four isolates shared 87.4–90.7 % nucleotide homology with the Lelystad strain (PRRSV-Type 1 stereotype strain). NSP2, ORF3, and ORF4 were the most variable regions and contained discontinuous deletions or insertions when compared to other PRRSV-Type 1 strains. All isolates fell into separate branches of the subtype 1 of PRRSV-Type 1 phylogenetic tree. This analysis of emerging PRRSV-Type 1 strains revealed previously unrecorded genetic diversity. Close attention should be paid to the prevention and control of this evolving virus.
ISSN:0920-8569
1572-994X
DOI:10.1007/s11262-015-1256-z