Non-injected illicit drug use and infectious disease risk of donor tissue: a single institution retrospective review

This study assessed the relationship of non-injected illicit drug use and infectious disease seropositivity for human immunodeficiency virus (HIV-1), hepatitis B virus (HBV), hepatitis C virus (HCV), and Syphilis. In a retrospective review of 986 donor charts recovered from 2009 to 2011 at a single...

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Bibliographic Details
Published in:Cell and tissue banking 2015-12, Vol.16 (4), p.623-629
Main Authors: Barton, Mark D., Qureshi, Amir, Vijapura, Anita, Temple, H. Thomas
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Cell Biology
Drug use
Florida - epidemiology
Hepatitis B virus
Hepatitis C virus
HIV Seropositivity - epidemiology
Human immunodeficiency virus 1
Humans
Incidence
Infectious diseases
Life Sciences
Middle Aged
Nuclear polyhedrosis virus
Retrospective Studies
Risk Assessment
Skin & tissue grafts
Street Drugs
Studies
Substance-Related Disorders - epidemiology
Syphilis - epidemiology
Tissue Banks - statistics & numerical data
Tissue Donors - statistics & numerical data
Transplant Surgery
Treponema pallidum
Virus Diseases - epidemiology
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Summary:This study assessed the relationship of non-injected illicit drug use and infectious disease seropositivity for human immunodeficiency virus (HIV-1), hepatitis B virus (HBV), hepatitis C virus (HCV), and Syphilis. In a retrospective review of 986 donor charts recovered from 2009 to 2011 at a single tissue bank, the absence of reported non-injected illicit drug use corresponded with seropositivity in 6.61 %, of recovered donors while reported illicit drug use in the medical and social history corresponded with seropositivity in 11.25 %, representing a 70 % increased risk. There was no significant difference noted for overall seropositivity rates between types on noninjected illicit drugs, although donors that used cocaine had a higher incidence of HIV, while marijuana use was associated with a higher rate of HBV, HCV, and syphilis positivity. Toxicology screening results were not an accurate predictor of seropositivity (PPV = 3.77 %; NPV = 91.56 %). Further, the degree of relationship between the donor and the next of kin had no bearing on the veracity of actual drug use when comparing the response of the medical-social history and the toxicology screen.
ISSN:1389-9333
1573-6814
DOI:10.1007/s10561-015-9511-z