Rising incidence and aggressive nature of cutaneous malignancies after transplantation: An update on epidemiology, risk factors, management and surveillance

• Published in: Surgical oncology 2015-12, Vol.24 (4), p.345-352
• Main Authors: Tufaro, Anthony P, Azoury, Saïd C, Crompton, Joseph G, Straughan, David M, Reddy, Sashank, Prasad, Nijaguna B, Shi, Gang, Fischer, Anne C
• Format: Article
• Language: English
• Subjects: Age; Collaboration; Cutaneous malignancy; Disease Management; Epidemiology; Health risk assessment; Hematology, Oncology and Palliative Medicine; Humans; Immunosuppression; Incidence; Melanoma; Mortality; Organ Transplantation - adverse effects; Patients; Population; Prognosis; Risk Factors; Skin cancer; Skin Neoplasms - diagnosis; Skin Neoplasms - epidemiology; Skin Neoplasms - etiology; Skin Neoplasms - prevention & control; Surgery; Surveillance; Transplant; Transplants & implants
• ISSN: 0960-7404; 1879-3320
• DOI: 10.1016/j.suronc.2015.09.007

Abstract Although immunosuppression has been a key component to the success of solid-organ transplantation, the morbidity associated with long-term immunosuppression remains a substantial burden, particularly as recipients of transplants live longer. Indeed, malignancy is one of the most common reasons for mortality following transplantation and the most common of these cancers are cutaneous in origin. Recently, the incidence of these malignancies has been on the rise, partly due to the fact that recipients of these transplants are living longer as a result of improvements in surgical technique, immunosuppression and perioperative management. Although there have been initiatives to increase awareness of cutaneous malignancies following transplantation, such programs are not standardized and there continues to be gaps in skin cancer education and post-operative surveillance. This review provides an update on the epidemiology, risk factors, clinical management, prevention and surveillance of cutaneous malignancies.