Blood transfusion does not affect survival of gastric cancer patients

Abstract Background To initially assess the impact of perioperative blood transfusions (PBTs) on overall survival of patients underwent curative resection of Ⅰ–Ⅲ TNM stage gastric cancer (GC) using the propensity scoring method. Methods The medical records of 1150 GC patients who underwent curative...

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Bibliographic Details
Published in:The Journal of surgical research 2016-01, Vol.200 (1), p.98-104
Main Authors: Cui, Jingli, PhD, Deng, Jingyu, MD, Ding, Xuewei, MD, Zhang, Li, PhD, Zhang, Rupeng, MD, Wu, Weipeng, PhD, Hao, Xishan, MD, Liang, Han, MD
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Adult
Aged
Aged, 80 and over
Blood transfusion
Female
Follow-Up Studies
Gastrectomy
Gastric cancer
Humans
Male
Middle Aged
Neoplasm Staging
Perioperative Care - adverse effects
Perioperative Care - methods
Prognosis
Propensity Score
Propensity score analysis
Retrospective Studies
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Surgery
Survival Analysis
Transfusion Reaction
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Summary:Abstract Background To initially assess the impact of perioperative blood transfusions (PBTs) on overall survival of patients underwent curative resection of Ⅰ–Ⅲ TNM stage gastric cancer (GC) using the propensity scoring method. Methods The medical records of 1150 GC patients who underwent curative resection in the Tianjin Cancer Hospital between 2003 and 2008 were retrospectively analyzed. Both transfusion and nontransfusion patients were assessed the prognostic differences after surgery using the propensity score analysis. Results A total of 299 GC patients (26.0%) were administrated the PBT. With the unadjusted analysis, patients with PBT presented older age, more operative blood loss, lower hemoglobin, lower albumin level, and higher risk of the advanced disease. The 5-y survival rate for patients with PBT was 31.0%, which was significantly lower than that (47.9%) of patients without PBT ( P   0.05). In addition, we also found that PBT was not significantly associated with the increasing risk of mortality (hazard ratio, 1.054; P  = 0.628). Conclusions PBT could not give rise to the worse prognoses of GC patients.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2015.07.019