The ratio of oxidized and reduced forms of selected antioxidants as a possible marker of oxidative stress in humans

Oxidative stress is an imbalance between reactive oxygen species exposure and the ability of organisms to detoxify the reactive intermediates and to repair the oxidative damage of biologically important molecules. Many clinical studies of oxidative stress unfortunately provide conflicting and contra...

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Bibliographic Details
Published in:Biomedical chromatography 2016-01, Vol.30 (1), p.13-28
Main Author: Kanďár, Roman
Format: Article
Language:English
Subjects:
allantoin
Animals
antioxidants
Antioxidants - chemistry
ascorbic acid
Biomarkers - chemistry
coenzyme Q10
glutathione
Humans
Oxidation-Reduction
Oxidative Stress
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Summary:Oxidative stress is an imbalance between reactive oxygen species exposure and the ability of organisms to detoxify the reactive intermediates and to repair the oxidative damage of biologically important molecules. Many clinical studies of oxidative stress unfortunately provide conflicting and contradictory results. The ability of antioxidant systems to adequately respond to oxidative stress can be used in laboratory diagnostics. In the present review, methods using the ratio of reduced and oxidized forms of uric acid, ascorbic acid, glutathione and coenzyme Q10 as suitable indicators of oxidative stress are discussed. From the mentioned publications it is evident that suitable sample preparation prior to analysis is crucial. Copyright © 2015 John Wiley & Sons, Ltd.
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.3529