The upper reference limit for thyroid peroxidase autoantibodies is method-dependent: A collaborative study with biomedical industries

The determination of the upper reference limit (URL) for thyroid peroxidase autoantibodies (TPOAbs) is a contentious issue, because of the difficulty in defining the reference population. The aim of this study was to establish the URL (eURL) for TPOAbs, according to the National Academy of Clinical...

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Bibliographic Details
Published in:Clinica chimica acta 2016-01, Vol.452, p.61-65
Main Authors: Tozzoli, Renato, D'Aurizio, Federica, Ferrari, Anna, Castello, Roberto, Metus, Paolo, Caruso, Beatrice, Perosa, Anna Rosa, Sirianni, Francesca, Stenner, Elisabetta, Steffan, Agostino, Villalta, Danilo
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoantibodies - immunology
Autoantigens - immunology
Autoimmune thyroid diseases
Automation
Female
Harmonization
Humans
Immunoassay
Immunoassay - methods
Iodide Peroxidase - immunology
Iron-Binding Proteins - immunology
Male
Reference Values
Sex Characteristics
Thyroid peroxidase autoantibodies
Upper reference limit
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Summary:The determination of the upper reference limit (URL) for thyroid peroxidase autoantibodies (TPOAbs) is a contentious issue, because of the difficulty in defining the reference population. The aim of this study was to establish the URL (eURL) for TPOAbs, according to the National Academy of Clinical Biochemistry (NACB) guidelines and to compare them with those obtained in a female counterpart, by the use of six commercial automated platforms. 120 healthy males and 120 healthy females with NACB-required characteristics (
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2015.10.025