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Post-radiation Plasma Epstein-Barr Virus DNA and Local Clinical Remission After Radical Intensity-modulated Radiation Therapy for Nasopharyngeal Carcinoma

Abstract Aims We studied if post-radiation plasma Epstein-Barr virus (EBV) DNA predicted local clinical remission after radical intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma. Materials and methods Patients with non-metastatic nasopharyngeal carcinoma with baseline and ser...

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Published in:Clinical oncology (Royal College of Radiologists (Great Britain)) 2016-01, Vol.28 (1), p.42-49
Main Authors: Lee, V.H.F, Kwong, D.L.W, Leung, T.W, Choi, C.W, Lam, K.O, Sze, C.K, Ho, P, Chan, W.L, Wong, L.S, Leung, D
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Language:English
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Summary:Abstract Aims We studied if post-radiation plasma Epstein-Barr virus (EBV) DNA predicted local clinical remission after radical intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma. Materials and methods Patients with non-metastatic nasopharyngeal carcinoma with baseline and serial plasma EBV DNA were treated with radical IMRT ± adjunct chemotherapy. Eight weeks after IMRT, they had plasma EBV DNA and routine six-site random nasopharyngeal biopsies on the same day. A repeat biopsy was carried out every 2 weeks if residual tumours were noted in previous biopsies until 12 weeks after IMRT when local persistence was defined. Correlation of undetectable plasma EBV DNA with local clinical remission was carried out. Results Two hundred and sixty patients with serial plasma EBV DNA completed IMRT, after a median follow-up of 3.1 years. Only one (0.4%) suffered from local persistence. Area under the curve values of receiver operating characteristics of undetectable plasma EBV DNA for negative biopsy at 8 weeks and local persistence were 0.642 and 0.439, respectively. They increased to 0.856 ( P  = 0.007) and 0.952 ( P  = 0.119), respectively, when combined with age
ISSN:0936-6555
1433-2981
DOI:10.1016/j.clon.2015.09.009