Hepatocellular carcinoma and lifestyles

Summary The majority of hepatocellular carcinoma occurs over pre-existing chronic liver diseases that share cirrhosis as an endpoint. In the last decade, a strong association between lifestyle and hepatocellular carcinoma has become evident. Abundance of energy-rich food and sedentary lifestyles hav...

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Bibliographic Details
Published in:Journal of hepatology 2016-01, Vol.64 (1), p.203-214
Main Authors: Saran, Uttara, Humar, Bostjan, Kolly, Philippe, Dufour, Jean-François
Format: Article
Language:English
Subjects:
Alcohol Drinking - adverse effects
Carcinoma, Hepatocellular - etiology
Coffee
Diet
Exercise
Gastroenterology and Hepatology
Humans
Inflammation - complications
Life Style
Liver Neoplasms - etiology
Smoking - adverse effects
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Summary:Summary The majority of hepatocellular carcinoma occurs over pre-existing chronic liver diseases that share cirrhosis as an endpoint. In the last decade, a strong association between lifestyle and hepatocellular carcinoma has become evident. Abundance of energy-rich food and sedentary lifestyles have caused metabolic conditions such as obesity and diabetes mellitus to become global epidemics. Obesity and diabetes mellitus are both tightly linked to non-alcoholic fatty liver disease and also increase hepatocellular carcinoma risk independent of cirrhosis. Emerging data suggest that physical activity not only counteracts obesity, diabetes mellitus and non-alcoholic fatty liver disease, but also reduces cancer risk. Physical activity exerts significant anticancer effects in the absence of metabolic disorders. Here, we present a systematic review on lifestyles and hepatocellular carcinoma.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2015.08.028