Evaluating and mitigating fracture risk in established rheumatoid arthritis

Abstract Patients with rheumatoid arthritis are predisposed to systemic bone loss, and they are at an increased risk of fractures. Although there are similarities in the patient demographics between rheumatoid arthritis patients and the general population of osteoporosis patients, there are factors,...

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Bibliographic Details
Published in:Best practice & research. Clinical rheumatology 2015-08, Vol.29 (4), p.614-627
Main Authors: Mullen, Matthew B, Saag, Kenneth G
Format: Article
Language:English
Subjects:
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Bone Resorption - diagnosis
Bone Resorption - etiology
Bone Resorption - prevention & control
Fracture risk
Fractures, Bone - diagnosis
Fractures, Bone - etiology
Fractures, Bone - prevention & control
Glucocorticoid-induced osteoporosis
Glucocorticoids - therapeutic use
Humans
Life Style
Osteoporosis
Osteoporosis - diagnosis
Osteoporosis - etiology
Osteoporosis - prevention & control
Rheumatoid arthritis
Rheumatology
Risk Assessment
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Summary:Abstract Patients with rheumatoid arthritis are predisposed to systemic bone loss, and they are at an increased risk of fractures. Although there are similarities in the patient demographics between rheumatoid arthritis patients and the general population of osteoporosis patients, there are factors, particularly the use of glucocorticoids, which are specific to rheumatoid arthritis. These factors can lead to an increased risk of bone loss and fracture. Given that fractures are often very debilitating, especially in elderly patients, it is of paramount importance for the practicing rheumatologist to be aware of ways to reduce the risk of fracture in patients with rheumatoid arthritis. This review discusses currently available modalities for fracture risk assessment as well as pharmacologic and lifestyle interventions available to treat and prevent bone loss in rheumatoid arthritis patients.
ISSN:1521-6942
1532-1770
DOI:10.1016/j.berh.2015.09.005