The Associations of Adolescent Cigarette Smoking, Alcoholic Beverage Consumption, Environmental Tobacco Smoke, and Ionizing Radiation with Subsequent Breast Cancer Risk (United States)

Objectives: Studies of breast cancer among survivors of the World War II atomic bomb blasts over Japan suggest that the adolescent breast may be particularly sensitive to carcinogenic insult. To further explore that possibility we examined the relationships of cigarette smoking, alcohol consumption,...

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Bibliographic Details
Published in:Cancer causes & control 2000-03, Vol.11 (3), p.271-278
Main Authors: Marcus, Pamela M., Newman, Beth, Millikan, Robert C., Moorman, Patricia G., Baird, Donna Day, Qaqish, Bahjat
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Adolescent Behavior
Adolescents
Adult
African Americans
Age
Alcohol
Alcohol drinking
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Alcoholic beverages
Body mass index
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - etiology
Carcinogens
Case control studies
Child
Child development
Cigarette smoking
Cigarettes
Commentary
Female
Humans
Ionizing radiation
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Radiation-Induced - etiology
North Carolina - epidemiology
Nuclear weapons
Odds Ratio
Radiation
Radiation, Ionizing
Response rates
Risk Factors
Secondhand smoke
Smoking
Smoking - adverse effects
Smoking - epidemiology
Tobacco smoke
Tobacco Smoke Pollution - adverse effects
Tobacco Smoke Pollution - statistics & numerical data
Womens health
World War II
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Summary:Objectives: Studies of breast cancer among survivors of the World War II atomic bomb blasts over Japan suggest that the adolescent breast may be particularly sensitive to carcinogenic insult. To further explore that possibility we examined the relationships of cigarette smoking, alcohol consumption, environmental tobacco smoke (ETS) exposure, and medical treatment with ionizing radiation during adolescence with subsequent breast cancer risk. Methods: Data from the Carolina Breast Cancer Study, a population-based, case-control study of breast cancer in North Carolina women aged 20-74 years (864 cases, 790 controls), were analyzed. Results: A modest increase in breast cancer risk was suggested for women who began to smoke cigarettes between the ages of 10 and 14 years (OR: 1.5, CI: 0.9-2.5), and for women exposed to ionizing radiation between ages 10 and 19 years to treat or monitor a medical condition (OR: 1.6, CI: 0.5-2.5). Neither exposure to ETS at home prior to age 18 years (OR: 1.1, CI: 0.9-1.3) nor initiation of alcoholic beverage consumption between ages 10 and 15 years (OR: 1.1, CI: 0.6-1.8) appeared to increase risk. Conclusions: Our results are consistent with previous evidence suggesting that some adolescent exposures could influence future breast cancer risk.
ISSN:0957-5243
1573-7225
DOI:10.1023/A:1008911902994