Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery

Highlights • Circulating maternal cortisol levels are lower in very severely obese pregnancy than in lean pregnancy. • Other key hormones regulating pregnancy cortisol levels including CRH and CBG are lower in obese pregnancy. • A lack of increase in urinary glucocorticoid clearance suggests a lesse...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-01, Vol.63, p.135-143
Main Authors: Stirrat, Laura I, O’Reilly, James R, Barr, Sarah M, Andrew, Ruth, Riley, Simon C, Howie, Alexander F, Bowman, Maria, Smith, Roger, Lewis, John G, Denison, Fiona C, Forbes, Shareen, Seckl, Jonathan R, Walker, Brian R, Norman, Jane E, Reynolds, Rebecca M
Format: Article
Language:English
Subjects:
Adult
Birth Weight
Case-Control Studies
Corticotropin-Releasing Hormone - metabolism
Cortisone - urine
Endocrinology & Metabolism
Estradiol - metabolism
Estriol - metabolism
Female
Gestational Age
Humans
Hydrocortisone - metabolism
Hypothalamo-Hypophyseal System - metabolism
Infant, Low Birth Weight
Infant, Newborn
Male
Obesity, Morbid - metabolism
Pituitary-Adrenal System - metabolism
Pregnancy
Pregnancy Complications - metabolism
Pregnanes - urine
Progesterone - metabolism
Psychiatry
Tetrahydrocortisol - urine
Transcortin - metabolism
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Summary:Highlights • Circulating maternal cortisol levels are lower in very severely obese pregnancy than in lean pregnancy. • Other key hormones regulating pregnancy cortisol levels including CRH and CBG are lower in obese pregnancy. • A lack of increase in urinary glucocorticoid clearance suggests a lesser activation of the HPAA in obese pregnancy. • This may offer a novel mechanism underlying increased birth weight and longer gestation in obese pregnancy.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2015.09.019