Do Muscle Characteristics on Lumbar Spine Magnetic Resonance Imaging or Computed Tomography Predict Future Low Back Pain, Physical Function, or Performance? A Systematic Review

• Published in: PM & R 2015-12, Vol.7 (12), p.1269-1281
• Main Authors: Suri, Pradeep, MD, MS, Fry, Adrielle L., MD, Gellhorn, Alfred C., MD
• Format: Article
• Language: English
• Subjects: Humans; Low Back Pain - diagnosis; Low Back Pain - physiopathology; Low Back Pain - rehabilitation; Lumbar Vertebrae - diagnostic imaging; Lumbar Vertebrae - pathology; Magnetic Resonance Imaging - methods; Movement - physiology; Paraspinal Muscles - diagnostic imaging; Paraspinal Muscles - pathology; Paraspinal Muscles - physiopathology; Physical Medicine and Rehabilitation; Tomography, X-Ray Computed - methods
• ISSN: 1934-1482; 1934-1563
• DOI: 10.1016/j.pmrj.2015.04.016

Abstract Objective To determine whether lumbar muscle characteristics on magnetic resonance imaging (MRI) or computed tomography (CT) can inform clinicians as to the course of future low back pain (LBP), functional limitations, or physical performance, in adults with or without LBP. Type Systematic review. Literature Review We searched PubMed, Embase, and CINAHL through October 2014 for articles published in English in which authors assessed lumbar muscle characteristics on conventional MRI/CT as predictors of future LBP, functional limitations, or physical performance in adults. Studies with only postsurgical subjects were excluded. Our search identified 3554 articles, of which 6 observational cohort studies were included in the final review. Methodology We used the Newcastle Ottawa Scale to evaluate potential bias. Data were extracted on study design, study population, sample size, participant characteristics, details of MRI/CT assessments, interventions, study outcomes, analysis methods, and study results. Because of heterogeneity between studies, we conducted a qualitative evidence synthesis. Synthesis Among high-quality studies, there was limited evidence that, for individuals with or without LBP, greater MRI-detected multifidus cross-sectional area at L5-S1 predicted greater LBP intensity at 1-year follow-up, lesser erector spinae fat infiltration (FI) at L5-S1 predicted greater LBP intensity at 15-year follow-up, and greater erector spinae side-to-side FI asymmetry at L3-L4 predicted lower LBP frequency at 15-year follow-up; however, there was also limited evidence that all other MRI-detected paraspinal muscle characteristics examined were not predictive of LBP incidence, prevalence, frequency, or intensity at follow-up durations ranging from 1 to 15 years. There was limited evidence that greater CT-detected trunk muscle FI predicted worse physical performance in older adults at 3-year follow-up, but that trunk muscle cross-sectional area did not. Conclusion Few lumbar muscle characteristics have limited evidence for an association with future LBP and physical performance outcomes, and the vast majority have limited evidence for having no association with such outcomes.