Inexplicable Outcome of Early Appearance of Hepatocellular Carcinoma in the Allograft After Deceased Donor Liver Transplantation: A Case Report

Abstract Background This case represents the earliest appearance of de novo HCC after liver transplantation (OLT) compared with cases of previously reported literatures. Case Report A 45-year-old man underwent deceased donor OLT owing to decompensated liver cirrhosis. He had YMDD viral mutation and...

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Bibliographic Details
Published in:Transplantation proceedings 2015-12, Vol.47 (10), p.3012-3015
Main Authors: Navarro Burgos, J.B, Lee, K.-W, Shin, Y.C, Lee, D.S, Lee, K.B, Yi, N.J, Suh, K.-S
Format: Article
Language:English
Subjects:
Allografts
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Female
Follow-Up Studies
Humans
Liver Cirrhosis - complications
Liver Cirrhosis - surgery
Liver Failure - etiology
Liver Failure - surgery
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Liver Transplantation - adverse effects
Male
Middle Aged
Surgery
Time Factors
Tissue Donors
Transplant Recipients
Young Adult
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Summary:Abstract Background This case represents the earliest appearance of de novo HCC after liver transplantation (OLT) compared with cases of previously reported literatures. Case Report A 45-year-old man underwent deceased donor OLT owing to decompensated liver cirrhosis. He had YMDD viral mutation and hepatitis B (HBV) and C (HCV) coinfection but no tumor was found in the liver on MRI before OLT. The donor was a healthy young female donor who was HCV and HBV negative. There was no tumor in the explant liver. After OLT, HCV RNA and hepatitis B surface antigen became undetectable with DNA-positive HBV. Nine months after OLT, a computed tomography (CT) scan was performed owing to abdominal pain, detecting a mass occupying the right lobe that depicted enhanced characteristics typical of HCC. The chest CT demonstrated metastatic lung nodules in the right basal lower lobe. Fluorescence in situ hybridization showed tumor cells from the recipient. Conclusions To the best of our knowledge, this is the first report of de novo hepatocellular carcinoma that has emerged within a short period of undergoing OLT.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2015.10.040