A new single-dose bivalent vaccine of porcine circovirus type 2 and Mycoplasma hyopneumoniae elicits protective immunity and improves growth performance under field conditions

•The bivalent vaccine elicited immune responses against PCV2 and M. hyopneumoniae.•Pigs vaccinated with the bivalent vaccine decreased mortality rate of 13.4%.•Pigs vaccinated with the bivalent vaccine increased market weight of 6.2kg/pig. The efficacy of the new single-dose bivalent vaccine of porc...

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Bibliographic Details
Published in:Veterinary microbiology 2016-01, Vol.182, p.178-186
Main Authors: Jeong, Jiwoon, Park, Changhoon, Choi, Kyuhyung, Chae, Chanhee
Format: Article
Language:English
Subjects:
Animals
Bacterial Vaccines - immunology
Bacterial Vaccines - therapeutic use
Bivalent vaccine
Circoviridae Infections - immunology
Circoviridae Infections - veterinary
Circovirus - classification
Circovirus - immunology
Coinfection - immunology
Coinfection - prevention & control
Female
Mycoplasma hyopneumoniae
Mycoplasma hyopneumoniae - immunology
Pneumonia of Swine, Mycoplasmal - immunology
Pneumonia of Swine, Mycoplasmal - prevention & control
Porcine circovirus type 2
Porcine respiratory disease complex
Sus scrofa - growth & development
Sus scrofa - immunology
Swine
Swine Diseases - immunology
Swine Diseases - microbiology
Swine Diseases - virology
Vaccination - veterinary
Vaccines, Combined - immunology
Vaccines, Combined - therapeutic use
Viral Vaccines - immunology
Viral Vaccines - therapeutic use
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Summary:•The bivalent vaccine elicited immune responses against PCV2 and M. hyopneumoniae.•Pigs vaccinated with the bivalent vaccine decreased mortality rate of 13.4%.•Pigs vaccinated with the bivalent vaccine increased market weight of 6.2kg/pig. The efficacy of the new single-dose bivalent vaccine of porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae was evaluated under field conditions for registration as recommended by the Republic of Korea’s Animal, Plant & Fisheries Quarantine & Inspection Agency. Three farms were selected based on their history of co-infection with PCV2 and M. hyopneumoniae. On each farm, a total of 80 3-week-old pigs were randomly allocated to one of two treatment groups: (i) vaccinated (n=40) and (ii) unvaccinated (n=40) animals at 3 weeks of age. Protection by the bivalent vaccine helped increase the market weight by 6.2kg/pig (106.2kg in vaccinated group vs. 100kg in unvaccinated group; P
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2015.11.023