Paradoxical effect of imipramine in hyperprolactinemic female rats exposed to the forced swimming test

This study was designed to investigate the effect of hyperprolactinemia, with high or low estrogen levels, on the response to imipramine in the forced swimming test. Three groups of female rats were studied: (1) ovariectomized controls, with low serum prolactin (PRL) and estrogen levels, (2) ovariec...

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Bibliographic Details
Published in:Physiology & behavior 2000-03, Vol.68 (5), p.619-623
Main Authors: Ribeiro, M.F., Ferigolo, M., Reis, F.M., Barros, H.M.T., Spritzer, P.M.
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Behavior, Animal - physiology
Estradiol
Estrogen
Female
Hyperprolactinemia
Hyperprolactinemia - chemically induced
Hyperprolactinemia - physiopathology
Imipramine
Imipramine - pharmacology
Locomotion - drug effects
Locomotion - physiology
Ovariectomy
Pituitary Gland, Anterior - metabolism
Pituitary Gland, Anterior - transplantation
Prolactin - blood
Rats
Rats, Wistar
Reaction Time - drug effects
Reaction Time - physiology
Swimming - physiology
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Summary:This study was designed to investigate the effect of hyperprolactinemia, with high or low estrogen levels, on the response to imipramine in the forced swimming test. Three groups of female rats were studied: (1) ovariectomized controls, with low serum prolactin (PRL) and estrogen levels, (2) ovariectomized, estrogen-treated rats, with high PRL and high estrogen levels, and (3) pituitary-grafted rats, with high PRL and low estrogen levels. The hyperprolactinemic groups did not show significant behavioral changes in the forced swimming test preceded by saline injection. Imipramine decreased the immobility time by 37.5% in ovariectomized controls but not in the pituitary-grafted group, and there was an increment of 48.4% in immobility time following imipramine administration in the estrogen-treated group ( p < 0.05). This paradoxical response to imipramine was significantly correlated with serum PRL ( r = 0.59, p < 0.01) but not with estradiol levels. These findings suggest that, at least in female rats submitted to the forced swimming model, PRL may induce reversed behavioral effects in response to imipramine, independently of circulating estrogen levels.
ISSN:0031-9384
1873-507X
DOI:10.1016/S0031-9384(99)00199-7