Acute neuropathy mimicking porphyria induced by aminolevulinic acid during photodynamic therapy

An 82‐year‐old man developed severe, acute, predominantly motor polyneuropathy, signs of autonomic involvement, and skin changes following aminolevulinic acid (ALA) administration. The compound was used as a prodrug for photodynamic therapy of Barrett's esophagitis. Changes were observed in var...

Full description

Saved in:
Bibliographic Details
Published in:Muscle & nerve 2005-03, Vol.31 (3), p.390-393
Main Authors: Sylantiev, Constantin, Schoenfeld, Nili, Mamet, Rivka, Groozman, Galina B., Drory, Vivian E.
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Aged, 80 and over
aminolevulinic acid
Aminolevulinic Acid - adverse effects
Barrett Esophagus - drug therapy
Biological and medical sciences
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Diagnosis, Differential
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Nervous system (semeiology, syndromes)
Nervous System Diseases - chemically induced
Nervous System Diseases - diagnosis
Neurology
Other diseases. Semiology
Photochemotherapy - adverse effects
photodynamic therapy
Photosensitizing Agents - adverse effects
polyneuropathy
Porphyria
Porphyrias - diagnosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An 82‐year‐old man developed severe, acute, predominantly motor polyneuropathy, signs of autonomic involvement, and skin changes following aminolevulinic acid (ALA) administration. The compound was used as a prodrug for photodynamic therapy of Barrett's esophagitis. Changes were observed in various parameters of the heme pathway. The case reported represents a rare response to ALA treatment, resembling an acute attack of hepatic porphyria with neurological features. Muscle Nerve, 2005
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.20167