NQO1 T allele associated with decreased risk of later age at diagnosis lung cancer among never smokers: results from a population-based study

The NAD(P)H:quinone oxidoreductase 1 gene, NQO1, contains a C to T transition at amino acid codon 187, which results in very low enzymatic activity. Previous studies of the association between NQO1 genotype and lung cancer have had mixed findings. This population-based case control study examines th...

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Bibliographic Details
Published in:Carcinogenesis (New York) 2005-02, Vol.26 (2), p.381-386
Main Authors: Bock, C.H., Wenzlaff, A.S., Cote, M.L., Land, S.J., Schwartz, A.G.
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Case-Control Studies
environmental tobacco smoke
ETS
Female
Genetic Predisposition to Disease
Humans
Lung Neoplasms - genetics
Male
Medical sciences
Middle Aged
NAD(P)H Dehydrogenase (Quinone) - genetics
Polymorphism, Single Nucleotide - genetics
Smoking - adverse effects
Tumors
Citations: Items that cite this one
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Summary:The NAD(P)H:quinone oxidoreductase 1 gene, NQO1, contains a C to T transition at amino acid codon 187, which results in very low enzymatic activity. Previous studies of the association between NQO1 genotype and lung cancer have had mixed findings. This population-based case control study examines the association between NQO1 genotype and lung cancer in the largest sample of never smokers (
ISSN:0143-3334
1460-2180
1460-2180
DOI:10.1093/carcin/bgh314