The influence of age on the treadmill exercise-induced c-Fos expression in the hippocampus of rats

c‐Fos has been used as a neuronal activity marker. Here, we examined the influence of age on the treadmill running‐induced c‐Fos expression in rat hippocampus. Rats of exercise groups were forces to run on treadmill for 30 min. once a day for 5 consecutive days. Without exercise, c‐Fos expression wa...

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Bibliographic Details
Published in:Neuroscience research communications 2004-07, Vol.35 (1), p.41-50
Main Authors: Kim, Sang-Ho, Kim, Hong, Kim, Sung-Soo, Shin, Mal-Soon, Chang, Hyun-Kyung, Lee, Taeck-Hyun, Jang, Mi-Hyeon, Shin, Min-Chul, Lee, Hee-Hyuk, Kim, Young-Pyo, Kim, Chang-Ju
Format: Article
Language:English
Subjects:
age
c-Fos
hippocampus
immunohistochemistry
treadmill exercise
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Summary:c‐Fos has been used as a neuronal activity marker. Here, we examined the influence of age on the treadmill running‐induced c‐Fos expression in rat hippocampus. Rats of exercise groups were forces to run on treadmill for 30 min. once a day for 5 consecutive days. Without exercise, c‐Fos expression was highest in 8‐week old rats. Treadmill exercise significantly enhanced the c‐Fos expression in the hippocampus of rats in all ages. In the CA region, the increase of the c‐Fos expression by treadmill exercise was highest in 4‐week old rats. In the dentate gyrus, the increase of the c‐Fos expression by treadmill exercise was highest in 62‐week old rats. The data show that age is an important factor for the regulation of the c‐Fos expression in the hippocampus and that the ability of the treadmill exercise enhancing the c‐Fos expression is dependent on age status.
ISSN:0893-6609
1520-6769
DOI:10.1002/nrc.20018