The predictive value of high sensitivity-troponin velocity within the first 6h of presentation for cardiac outcomes regardless of acute coronary syndrome diagnosis

Low-range troponin elevations without clear coronary manifestations remain a major diagnostic challenge. We sought to determine if troponin velocity could allow for early identification of patients without an obvious cardiac diagnosis and who are at increased risk for cardiac-specific events. All pa...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cardiology 2016-02, Vol.204, p.106-111
Main Authors: Chuang, Anthony, Hancock, David G., Horsfall, Matthew, Alhammad, Nasser J., Zhou, Julia, Cullen, Louise, French, John, Chew, Derek P.
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - epidemiology
Aged
Aged, 80 and over
Biomarkers - blood
Cohort Studies
Early Diagnosis
Female
hs-Troponin
Humans
Male
Middle Aged
Myocardial infarction
Predictive Value of Tests
Prospective Studies
Risk prediction
South Australia - epidemiology
Time Factors
Treatment Outcome
Troponin T - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Low-range troponin elevations without clear coronary manifestations remain a major diagnostic challenge. We sought to determine if troponin velocity could allow for early identification of patients without an obvious cardiac diagnosis and who are at increased risk for cardiac-specific events. All patients presenting to South Australian public hospitals between 1 September 2011 and 30 September 2012, with at least two troponin measurements during the first 6h after ED presentation were included. Diagnoses were classified as ‘coronary’, ‘non-coronary cardiac’, and ‘non-cardiac’ using the International Classification of Diseases 10 codes. The relationship between troponin velocity and cardiac-specific mortality and combined cardiac outcome (death and myocardial infarction) was assessed using Fine and Gray competing risk models in patients with an initial troponin
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2015.11.132