Sublingual vs. Oral Captopril in Hypertensive Crisis

Abstract Background There are confusing data in literature regarding oral and sublingual captopril effects over blood pressure (BP) decrease. Objectives In our study we compared oral and sublingual captopril effectiveness over BP decrease in patients admitted to our Emergency Department with hyperte...

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Bibliographic Details
Published in:The Journal of emergency medicine 2016-01, Vol.50 (1), p.108-115
Main Authors: Kaya, Adnan, MD, Tatlisu, Mustafa Adem, MD, Kaplan Kaya, Tugba, Pharm, Yildirimturk, Ozlem, MD, Gungor, Baris, MD, Karatas, Baran, MD, Yazici, Selcuk, MD, Keskin, Muhammed, MD, Avsar, Sahin, MD, Murat, Ahmet, MD
Format: Article
Language:English
Subjects:
Administration, Oral
Administration, Sublingual
Adult
Aged
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - pharmacology
Blood Pressure - drug effects
Captopril - administration & dosage
Captopril - pharmacology
Cross-Sectional Studies
Emergency
Female
Heart Rate - drug effects
Humans
Hypertension - drug therapy
hypertensive urgency
Male
Middle Aged
oral captopril
sublingual captopril
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Summary:Abstract Background There are confusing data in literature regarding oral and sublingual captopril effects over blood pressure (BP) decrease. Objectives In our study we compared oral and sublingual captopril effectiveness over BP decrease in patients admitted to our Emergency Department with hypertensive urgency. Methods Our study was conducted from January 2012 to January 2013 in patients with hypertensive urgency. In this cross-sectional study after two initial BP measurements, patients were identified as eligible for the study. An initial electrocardiogram was obtained and blood samples were drawn. A total of 212 patients were accepted as eligible for the study, and 25 mg of captopril was randomly given orally or sublingually; BP was measured at 10, 30, and 60 min. We selected the patients to the groups consecutively. A 25% reduction of initial BP 1 h after initiation of the treatment was accepted as an accomplishment. A second 25 mg of captopril was given if the target of 25% reduction of BP was not reached after the first tablet. Intravenous drugs were administered to the patients resistant to the captopril and these patients were excluded from the study. Results The 10-min systolic BP (SBP), diastolic BP, and mean BP (MBP) decrease was more prominent in the sublingual captopril group ( p  
ISSN:0736-4679
2352-5029
DOI:10.1016/j.jemermed.2015.07.017