Farrerol inhibits IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by suppressing PI3K/AKT/NF-κB signaling pathway

Highlights • Farrerol inhibits LPS-induced IL-6 and IL-8 production. • Farrerol inhibits LPS-induced NF-κB activation. • Farrerol inhibits LPS-induced PI3K and Akt phosphorylation.

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Bibliographic Details
Published in:Archives of oral biology 2016-02, Vol.62, p.28-32
Main Authors: Wang, Qian, Zhang, Bin, Yu, Jin-Long
Format: Article
Language:English
Subjects:
Advanced Basic Science
Anti-Bacterial Agents - pharmacology
Anti-Inflammatory Agents - pharmacology
Cell Survival - drug effects
Cells, Cultured
Chromones - pharmacology
Dentistry
Farrerol
Fibroblasts - drug effects
Gingiva - cytology
Gingiva - drug effects
Human gingival fibroblasts
Humans
IL-6
Interleukin-6 - antagonists & inhibitors
Interleukin-6 - biosynthesis
Interleukin-8 - antagonists & inhibitors
Interleukin-8 - biosynthesis
Lipopolysaccharides - pharmacology
NF-kappa B - antagonists & inhibitors
NF-kappa B - metabolism
NF-κB
Periodontal Diseases - therapy
Phosphatidylinositol 3-Kinases - antagonists & inhibitors
Phosphatidylinositol 3-Kinases - metabolism
Phosphorylation - drug effects
PI3K
Signal Transduction - drug effects
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Description
Summary:Highlights • Farrerol inhibits LPS-induced IL-6 and IL-8 production. • Farrerol inhibits LPS-induced NF-κB activation. • Farrerol inhibits LPS-induced PI3K and Akt phosphorylation.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.11.007