A New Antimitotic Substance, FR182877: I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities

Using the characteristic morphological changes of mammalian cells, we screened novel antimitotic substances and found that a strain of Streptomyces sp. No.9885 produced FR182877. This substance was isolated from the culture broth by ethyl acetate extraction, silica gel column chromatography and ODS...

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Bibliographic Details
Published in:Journal of antibiotics 2000/02/25, Vol.53(2), pp.123-130
Main Authors: SATO, BUNJI, MURAMATSU, HIDEYUKI, MIYAUCHI, MICHIYO, HORI, YASUHIRO, TAKASE, SHIGEHIRO, HINO, MOTOHIRO, HASHIMOTO, SEIJI, TERANO, HIROSHI
Format: Article
Language:English
Subjects:
Animals
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Applied microbiology
Biological and medical sciences
Cell Line
Chemotherapic agents
Cricetinae
Drug Screening Assays, Antitumor
Female
Fermentation
FR182877
Fundamental and applied biological sciences. Psychology
General aspects
Humans
Inhibitory Concentration 50
Kidney - cytology
Kidney - drug effects
Lethal Dose 50
Magnetic Resonance Spectroscopy
Medical sciences
Mice
Mice, Inbred Strains
Microbial Sensitivity Tests
Microbiology
Molecular Structure
Neoplasms, Experimental - drug therapy
Pharmacology. Drug treatments
Polycyclic Compounds - chemistry
Polycyclic Compounds - isolation & purification
Polycyclic Compounds - pharmacology
Streptomyces
Streptomyces - chemistry
Streptomyces - classification
Streptomyces - metabolism
Toxicity Tests
Tumor Cells, Cultured
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Summary:Using the characteristic morphological changes of mammalian cells, we screened novel antimitotic substances and found that a strain of Streptomyces sp. No.9885 produced FR182877. This substance was isolated from the culture broth by ethyl acetate extraction, silica gel column chromatography and ODS column chromatography. Structural studies on FR182877 suggested that it had a unique hexacyclic structure encompassing its highly strained double bond. FR182877 exhibited potent antitumor activities against murine ascitic tumor and solid tumor in vivo.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.123