Targeting fatty acid metabolism in cancer and endothelial cells

Highlights • Fatty acid oxidation is required for de novo synthesis of nucleotides in endothelial cell, thus functional angiogenesis. • The importance of other aspects of endothelial fatty acid metabolism requires further detailed investigation. • Cancer fatty acid metabolism is required for surviva...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2016-01, Vol.97, p.15-21
Main Authors: Harjes, Ulrike, Kalucka, Joanna, Carmeliet, Peter
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inhibitors - therapeutic use
Cancer cell metabolism
CPT1A
Endothelial cell metabolism
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Fatty acid metabolism
Fatty Acids - metabolism
Glycolysis - drug effects
Glycolysis - physiology
Hematology, Oncology and Palliative Medicine
Humans
Lipid Metabolism - drug effects
Molecular Targeted Therapy - methods
Molecular Targeted Therapy - trends
Neoplasms - blood supply
Neoplasms - metabolism
Neoplasms - therapy
Neovascularization, Pathologic - drug therapy
Neovascularization, Pathologic - metabolism
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Summary:Highlights • Fatty acid oxidation is required for de novo synthesis of nucleotides in endothelial cell, thus functional angiogenesis. • The importance of other aspects of endothelial fatty acid metabolism requires further detailed investigation. • Cancer fatty acid metabolism is required for survival and growth and to overcome periods of metabolic stress. • In cancer cells ATP and NADPH derived from fatty acid oxidation enable protection from ROS and energy maintenance. • Fatty acid oxidation is a potential target for anti-angiogenic therapies in cancer.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.10.011