Metabolic syndrome, independent of its components, affects adversely cardiovascular morbidity in essential hypertensives

Abstract Background The metabolic syndrome (MS) is widespread among hypertensive patients. However, the net impact of MS on major atherosclerotic events beyond the cardiovascular risk imposed by its individual components remains controversial in this group. We sought to assess both the independent a...

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Published in:Atherosclerosis 2016-01, Vol.244, p.66-72
Main Authors: Georgiopoulos, George, Tsioufis, Costas, Tsiachris, Dimitrios, Dimitriadis, Kyriakos, Kasiakogias, Alexandros, Lagiou, Fotini, Andrikou, Eirini, Ioannidis, Ioannis, Hatziagelaki, Erifili, Tousoulis, Dimitris
Format: Article
Language:English
Subjects:
Cardiovascular
Cardiovascular Diseases - epidemiology
Cardiovascular risk
Essential Hypertension
Female
Follow-Up Studies
Greece - epidemiology
Humans
Hypertension
Hypertension - epidemiology
Hypertension - etiology
Male
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Middle Aged
Morbidity - trends
Prognosis
Retrospective Studies
Risk Assessment - methods
Risk Factors
Survival Rate - trends
Time Factors
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Summary:Abstract Background The metabolic syndrome (MS) is widespread among hypertensive patients. However, the net impact of MS on major atherosclerotic events beyond the cardiovascular risk imposed by its individual components remains controversial in this group. We sought to assess both the independent and incremental prognostic role of MS for unfavorable cardiovascular events in a cohort of essential hypertensives. Methods We followed up 2176 essential hypertensives free of cardiovascular disease for a median period of 40 months. All subjects had at least one annual visit. MS was defined according to the updated NCEP III criteria. Endpoint of interest was the incidence of stroke, coronary artery disease (CAD) and their composite. Results MS was present at baseline in 819 hypertensives (37.6%). MS group presented increased prevalence of resistant hypertension in comparison to MS free group (18.4% versus 10.6%, p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.10.099