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Exposure to work-related levels of swine dust up-regulates CD106 on human alveolar macrophages
Background Exposure to dust from swine confinement buildings, causes an inflammatory response. Monocyte recruitment to the murine lung after instillation of lipopolysaccharide (LPS) has been shown to partially depend on CD106/VCAM1. We wanted to determine whether this can be confirmed in man. Method...
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| Published in: | American journal of industrial medicine 2004-10, Vol.46 (4), p.378-380 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4248-7d14750b7947942cd00e9d98e06cfd05945f58fb38c24913e62f92ed476d6c413 |
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| cites | cdi_FETCH-LOGICAL-c4248-7d14750b7947942cd00e9d98e06cfd05945f58fb38c24913e62f92ed476d6c413 |
| container_end_page | 380 |
| container_issue | 4 |
| container_start_page | 378 |
| container_title | American journal of industrial medicine |
| container_volume | 46 |
| creator | Hoffmann, Hans Jürgen Iversen, Martin Takai, Hisamitsu Sigsgaard, Torben Omland, Øyvind Dahl, Ronald |
| description | Background
Exposure to dust from swine confinement buildings, causes an inflammatory response. Monocyte recruitment to the murine lung after instillation of lipopolysaccharide (LPS) has been shown to partially depend on CD106/VCAM1. We wanted to determine whether this can be confirmed in man.
Methods
Non‐naïve persons bearing personal air samples were exposed for 3 hr in a swine confinement building, and were bronchoscopied before and after exposure. Blood samples were taken at the time of bronchoscopy. Expression of adhesion molecules on leukocytes was investigated by flow cytometry in bronchoaveloar lavage (BAL) and blood.
Results
Expression of CD106 on alveolar macrophages, but not on neutrophils or T cells in BAL or blood, was up‐regulated in proportion to the amount of LPS that individuals were exposed.
Conclusions
This argues for requirement of CD106 during inflammatory recruitment of monocytes to the human lung. Am. J. Ind. Med. 46:378–380, 2004. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajim.20078 |
| format | article |
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Exposure to dust from swine confinement buildings, causes an inflammatory response. Monocyte recruitment to the murine lung after instillation of lipopolysaccharide (LPS) has been shown to partially depend on CD106/VCAM1. We wanted to determine whether this can be confirmed in man.
Methods
Non‐naïve persons bearing personal air samples were exposed for 3 hr in a swine confinement building, and were bronchoscopied before and after exposure. Blood samples were taken at the time of bronchoscopy. Expression of adhesion molecules on leukocytes was investigated by flow cytometry in bronchoaveloar lavage (BAL) and blood.
Results
Expression of CD106 on alveolar macrophages, but not on neutrophils or T cells in BAL or blood, was up‐regulated in proportion to the amount of LPS that individuals were exposed.
Conclusions
This argues for requirement of CD106 during inflammatory recruitment of monocytes to the human lung. Am. J. Ind. Med. 46:378–380, 2004. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.20078</identifier><identifier>PMID: 15376213</identifier><identifier>CODEN: AJIMD8</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Air Pollutants, Occupational - metabolism ; Air Pollution, Indoor - analysis ; Animals ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid ; Bronchoscopes ; CD106/VCAM1 ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dust - analysis ; Endotoxins - analysis ; human ; Humans ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; lipopolysacchrides ; Macrophages, Alveolar - cytology ; Macrophages, Alveolar - metabolism ; Medical sciences ; monocyte/macrophage ; Swine ; swine confinement buildings ; Toxicology ; Up-Regulation ; Vascular Cell Adhesion Molecule-1 - analysis</subject><ispartof>American journal of industrial medicine, 2004-10, Vol.46 (4), p.378-380</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4248-7d14750b7947942cd00e9d98e06cfd05945f58fb38c24913e62f92ed476d6c413</citedby><cites>FETCH-LOGICAL-c4248-7d14750b7947942cd00e9d98e06cfd05945f58fb38c24913e62f92ed476d6c413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23930,23931,25140,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16179487$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15376213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoffmann, Hans Jürgen</creatorcontrib><creatorcontrib>Iversen, Martin</creatorcontrib><creatorcontrib>Takai, Hisamitsu</creatorcontrib><creatorcontrib>Sigsgaard, Torben</creatorcontrib><creatorcontrib>Omland, Øyvind</creatorcontrib><creatorcontrib>Dahl, Ronald</creatorcontrib><title>Exposure to work-related levels of swine dust up-regulates CD106 on human alveolar macrophages</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Background
Exposure to dust from swine confinement buildings, causes an inflammatory response. Monocyte recruitment to the murine lung after instillation of lipopolysaccharide (LPS) has been shown to partially depend on CD106/VCAM1. We wanted to determine whether this can be confirmed in man.
Methods
Non‐naïve persons bearing personal air samples were exposed for 3 hr in a swine confinement building, and were bronchoscopied before and after exposure. Blood samples were taken at the time of bronchoscopy. Expression of adhesion molecules on leukocytes was investigated by flow cytometry in bronchoaveloar lavage (BAL) and blood.
Results
Expression of CD106 on alveolar macrophages, but not on neutrophils or T cells in BAL or blood, was up‐regulated in proportion to the amount of LPS that individuals were exposed.
Conclusions
This argues for requirement of CD106 during inflammatory recruitment of monocytes to the human lung. Am. J. Ind. Med. 46:378–380, 2004. © 2004 Wiley‐Liss, Inc.</description><subject>Air Pollutants, Occupational - metabolism</subject><subject>Air Pollution, Indoor - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Bronchoscopes</subject><subject>CD106/VCAM1</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Dust - analysis</subject><subject>Endotoxins - analysis</subject><subject>human</subject><subject>Humans</subject><subject>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</subject><subject>lipopolysacchrides</subject><subject>Macrophages, Alveolar - cytology</subject><subject>Macrophages, Alveolar - metabolism</subject><subject>Medical sciences</subject><subject>monocyte/macrophage</subject><subject>Swine</subject><subject>swine confinement buildings</subject><subject>Toxicology</subject><subject>Up-Regulation</subject><subject>Vascular Cell Adhesion Molecule-1 - analysis</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp90M9PFDEUB_DGaGQBL_4Bphc5kAz017QzR1gRIYiGaEg82HTbNzDQmY7tDAv_vV13lZtJk3fo573XfhF6S8kBJYQdmru2O2CEqOoFmlFSq4IwJV6iWS604GUlt9B2SneEUCqkeI22aMmVZJTP0M-TxyGkKQIeA16GeF9E8GYEhz08gE84NDgt2x6wm9KIpyHf30wrkfD8AyUShx7fTp3psfEPELyJuDM2huHW3EDaRa8a4xO82dQd9P3jybf5p-Liy-nZ_OiisIKJqlCOClWShapFPsw6QqB2dQVE2saRshZlU1bNgleWiZpykKypGTihpJNWUL6D9tZzhxh-TZBG3bXJgvemhzAlTVXJeSVFhvtrmJ-YUoRGD7HtTHzSlOhVmnqVpv6TZsbvNlOnRQfumW7iy-D9BphkjW-i6W2bnp2k-TuVyo6u3bL18PSflfro_Ozz3-XFuqdNIzz-6zHxXkvFVamvL0_11fGP62P29Uor_hs665rd</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Hoffmann, Hans Jürgen</creator><creator>Iversen, Martin</creator><creator>Takai, Hisamitsu</creator><creator>Sigsgaard, Torben</creator><creator>Omland, Øyvind</creator><creator>Dahl, Ronald</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200410</creationdate><title>Exposure to work-related levels of swine dust up-regulates CD106 on human alveolar macrophages</title><author>Hoffmann, Hans Jürgen ; Iversen, Martin ; Takai, Hisamitsu ; Sigsgaard, Torben ; Omland, Øyvind ; Dahl, Ronald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4248-7d14750b7947942cd00e9d98e06cfd05945f58fb38c24913e62f92ed476d6c413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Air Pollutants, Occupational - metabolism</topic><topic>Air Pollution, Indoor - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>Bronchoscopes</topic><topic>CD106/VCAM1</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Dust - analysis</topic><topic>Endotoxins - analysis</topic><topic>human</topic><topic>Humans</topic><topic>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</topic><topic>lipopolysacchrides</topic><topic>Macrophages, Alveolar - cytology</topic><topic>Macrophages, Alveolar - metabolism</topic><topic>Medical sciences</topic><topic>monocyte/macrophage</topic><topic>Swine</topic><topic>swine confinement buildings</topic><topic>Toxicology</topic><topic>Up-Regulation</topic><topic>Vascular Cell Adhesion Molecule-1 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoffmann, Hans Jürgen</creatorcontrib><creatorcontrib>Iversen, Martin</creatorcontrib><creatorcontrib>Takai, Hisamitsu</creatorcontrib><creatorcontrib>Sigsgaard, Torben</creatorcontrib><creatorcontrib>Omland, Øyvind</creatorcontrib><creatorcontrib>Dahl, Ronald</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoffmann, Hans Jürgen</au><au>Iversen, Martin</au><au>Takai, Hisamitsu</au><au>Sigsgaard, Torben</au><au>Omland, Øyvind</au><au>Dahl, Ronald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to work-related levels of swine dust up-regulates CD106 on human alveolar macrophages</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>2004-10</date><risdate>2004</risdate><volume>46</volume><issue>4</issue><spage>378</spage><epage>380</epage><pages>378-380</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><coden>AJIMD8</coden><abstract>Background
Exposure to dust from swine confinement buildings, causes an inflammatory response. Monocyte recruitment to the murine lung after instillation of lipopolysaccharide (LPS) has been shown to partially depend on CD106/VCAM1. We wanted to determine whether this can be confirmed in man.
Methods
Non‐naïve persons bearing personal air samples were exposed for 3 hr in a swine confinement building, and were bronchoscopied before and after exposure. Blood samples were taken at the time of bronchoscopy. Expression of adhesion molecules on leukocytes was investigated by flow cytometry in bronchoaveloar lavage (BAL) and blood.
Results
Expression of CD106 on alveolar macrophages, but not on neutrophils or T cells in BAL or blood, was up‐regulated in proportion to the amount of LPS that individuals were exposed.
Conclusions
This argues for requirement of CD106 during inflammatory recruitment of monocytes to the human lung. Am. J. Ind. Med. 46:378–380, 2004. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15376213</pmid><doi>10.1002/ajim.20078</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0271-3586 |
| ispartof | American journal of industrial medicine, 2004-10, Vol.46 (4), p.378-380 |
| issn | 0271-3586 1097-0274 |
| language | eng |
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| source | Wiley |
| subjects | Air Pollutants, Occupational - metabolism Air Pollution, Indoor - analysis Animals Biological and medical sciences Bronchoalveolar Lavage Fluid Bronchoscopes CD106/VCAM1 Chemical and industrial products toxicology. Toxic occupational diseases Dust - analysis Endotoxins - analysis human Humans Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) lipopolysacchrides Macrophages, Alveolar - cytology Macrophages, Alveolar - metabolism Medical sciences monocyte/macrophage Swine swine confinement buildings Toxicology Up-Regulation Vascular Cell Adhesion Molecule-1 - analysis |
| title | Exposure to work-related levels of swine dust up-regulates CD106 on human alveolar macrophages |
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