Vaginal progesterone for prevention of preterm labor in asymptomatic twin pregnancies with sonographic short cervix: a randomized clinical trial of efficacy and safety

• Published in: Archives of gynecology and obstetrics 2016-01, Vol.293 (1), p.61-67
• Main Authors: El-Refaie, Waleed, Abdelhafez, Mohamed S, Badawy, Ahmed
• Format: Article
• Language: English
• Subjects: Administration, Intravaginal; Adolescent; Adult; Cervix Uteri - diagnostic imaging; Cervix Uteri - drug effects; Egypt - epidemiology; Female; Gestational Age; Humans; Incidence; Infant, Newborn; Obstetric Labor, Premature - prevention & control; Pregnancy; Pregnancy Outcome - epidemiology; Pregnancy, High-Risk; Pregnancy, Twin; Premature Birth - drug therapy; Premature Birth - epidemiology; Premature Birth - prevention & control; Progesterone - administration & dosage; Progesterone - pharmacology; Prospective Studies; Twins; Ultrasonography, Prenatal; Vagina - drug effects
• ISSN: 1432-0711
• DOI: 10.1007/s00404-015-3767-1

To evaluate the value of vaginal progesterone therapy for reduction of preterm labor in asymptomatic women with twin pregnancies and sonographic short cervix. This randomized controlled study was conducted in Mansoura University Hospital and private practice settings in Mansoura, Egypt. Of 322 women with dichorionic twin pregnancy, 250 asymptomatic women with cervical length of 20-25 mm at 20-24 weeks of gestation were included in the study. All women were randomly divided into two groups; the study group (n = 125) received vaginal progesterone suppositories in a dose of 400 mg daily starting at 20-24 weeks of gestation while the control group (n = 125) received no treatment. The primary outcome measure was preterm labor before 34 weeks of gestation and the secondary outcome measures were neonatal respiratory distress syndrome (RDS) and early neonatal death (END). 224 women (116 in the study group and 108 in the control group) were subjected to final analysis. The duration of pregnancy was significantly longer in the study group and the incidence of preterm labor before 34 and 32 weeks of gestation was significantly lower in the study group. The neonatal morbidities and mortality were significantly lower in the study group as shown by lower incidence of very low (