Childhood diarrhoea in Danish day care centres could be associated with infant colic, low birthweight and antibiotics

• Published in: Acta Paediatrica 2016-01, Vol.105 (1), p.90-95
• Main Authors: Hebbelstrup Jensen, Betina, Röser, Dennis, Andreassen, Bente Utoft, Olsen, Katharina E. P., Nielsen, Henrik Vedel, Roldgaard, Bent Bjørn, Schjørring, Susanne, Mirsepasi-Lauridsen, Hengameh Chloé, Jørgensen, Steffen L., Mortensen, Esben Munk, Petersen, Andreas Munk, Krogfelt, Karen Angeliki
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - adverse effects; Antibiotics; Child Day Care Centers; Child day care centres; Child, Preschool; Cohort study; Colic - complications; Day care centers; Denmark; Diarrhea - etiology; Diarrhea, Infantile - etiology; Diarrhoea; epidemiology; Female; Follow-Up Studies; Health risk assessment; Humans; Infant; Infant, Low Birth Weight; Male; Odds Ratio; Risk Factors; Surveys and Questionnaires
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/apa.13209

Aim Diarrhoea is very common in children attending day care centres. The aim of this study was to examine certain predisposing risk factors for an association with diarrhoea, including foreign travel, treatment with antibiotics, having household pets, infant colic, bottle feeding, using a pacifier and low birthweight. Methods A dynamic one‐year follow‐up cohort study comprising 179 children from 36 day care centres was conducted from September 2009 to July 2013 in Copenhagen, Denmark. Questionnaires were sent to the children's parents or legal guardians every two months for a year, requesting information on gastrointestinal symptoms and exposure. A logistic regression was performed to identify the odds ratios of different risk factors for diarrhoea. Results The odds ratios for diarrhoea were 1.97 (0.93–4.20) for children with a history of infant colic, 1.91 (0.90–4.04) for low birthweight children and 1.45 (0.74–2.82) for children who had used antibiotics. Having a pet in the household had a possible protective effect towards diarrhoeal events, with an odds ratio of 0.47 (0.20–1.09). Conclusion A history of infant colic, low birthweight, and to a lesser extent antibiotic use, possibly increased the risk of diarrhoea in Danish children in day care centres.