Carriage of Streptococcus pneumoniae in asymptomatic, community-dwelling elderly in the Netherlands

Highlights • Molecular techniques have high additional value for detecting the presence of S. pneumoniae in the upper respiratory tract of elderly. • Based on qPCR ( lytA ), up to one in five asymptomatic community-dwelling elderly are carriers of S. pneumoniae. • Conventional diagnostic culture und...

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Bibliographic Details
Published in:Vaccine 2016-01, Vol.34 (1), p.4-6
Main Authors: van Deursen, Anna M.M, van den Bergh, Menno R, Sanders, Elisabeth A.M
Format: Article
Language:English
Subjects:
Age
Aged
Allergy and Immunology
Carrier State - epidemiology
Carrier State - microbiology
Colonization
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Confidence intervals
Cross-Sectional Studies
Deoxyribonucleic acid
Diagnostic Tests, Routine - methods
Disease
DNA
Elderly
Female
Humans
Independent Living
Laboratories
Male
Meningitis
Methods
Mortality
Nasopharynx
Nasopharynx - microbiology
Netherlands - epidemiology
Older people
Oropharynx - microbiology
PCR
Pneumococcal Infections - epidemiology
Pneumococcal Infections - microbiology
Pneumonia
Prevalence
Research funding
Respiratory tract
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - isolation & purification
Studies
Vaccines
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Description
Summary:Highlights • Molecular techniques have high additional value for detecting the presence of S. pneumoniae in the upper respiratory tract of elderly. • Based on qPCR ( lytA ), up to one in five asymptomatic community-dwelling elderly are carriers of S. pneumoniae. • Conventional diagnostic culture underestimates S. pneumoniae colonization in elderly.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.11.014