CD45 Tyrosine Phosphatase Inhibitory Components from Aspergillus niger

Two inhibitors of CD45 tyrosine phosphatase, dihydrocarolic acid (1) and penitricin D (2), were isolated from a fermentation broth of the fungus Aspergillus niger and purified by HSCCC (high speed countercurrent chromatography) followed by HPLC. The structures were determined by NMR. The inhibitory...

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Bibliographic Details
Published in:Journal of antibiotics 2000/02/25, Vol.53(2), pp.110-113
Main Authors: ALVI, KHISAL A., NAIR, BIPIN G., RABENSTEIN, JOHN, DAVIS, GRACE, BAKER, DWIGHT D.
Format: Article
Language:English
Subjects:
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Aspergillus niger
Aspergillus niger - chemistry
Aspergillus niger - metabolism
Biological and medical sciences
Cell Division - drug effects
Cyclopropanes - pharmacology
dihydrocarolic acid
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Epidermal Growth Factor - pharmacology
Fermentation
Fibroblasts - drug effects
Fundamental and applied biological sciences. Psychology
Furans - isolation & purification
Furans - pharmacology
General aspects
Humans
Inhibitory Concentration 50
Leukocyte Common Antigens - drug effects
Leukocyte Common Antigens - metabolism
Magnetic Resonance Spectroscopy
Microbiology
Molecular Structure
penitricin D
Protein Tyrosine Phosphatases - antagonists & inhibitors
tyrosine phosphatase
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Description
Summary:Two inhibitors of CD45 tyrosine phosphatase, dihydrocarolic acid (1) and penitricin D (2), were isolated from a fermentation broth of the fungus Aspergillus niger and purified by HSCCC (high speed countercurrent chromatography) followed by HPLC. The structures were determined by NMR. The inhibitory activities of both compounds were specific to tyrosine phosphatases.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.53.110