Forensic evaluation and population genetic study of 30 insertion/deletion polymorphisms in a Chinese Yi group

Insertion/deletion polymorphisms have become a research hot spot in forensic science due to their tremendous potential in recent years. In the present study, we investigated 30 indel loci in a Chinese Yi ethnic group. The allele frequencies of the short allele of the 30 indel loci were in the range...

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Bibliographic Details
Published in:Electrophoresis 2015-05, Vol.36 (9-10), p.1196-1201
Main Authors: Zhang, Yu-Dang, Shen, Chun-Mei, Jin, Rui, Li, Ya-Ni, Wang, Bo, Ma, Li-Xia, Meng, Hao-Tian, Yan, Jiang-Wei, Dan Wang, Hong, Yang, Ze-Long, Zhu, Bo-Feng
Format: Article
Language:English
Subjects:
Asian Continental Ancestry Group - classification
Asian Continental Ancestry Group - genetics
China
Deletion
Discrimination
Ethnic Groups - classification
Ethnic Groups - genetics
Evaluation
Forensic application
Forensic engineering
Forensic Genetics
Forensic science
Genetic relationships
Genetics
Genetics, Population
Humans
Indel
INDEL Mutation - genetics
Insertion
Linkage Disequilibrium
Loci
Phylogeny
Polymorphism
Polymorphism, Genetic
Yi ethnic group
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Summary:Insertion/deletion polymorphisms have become a research hot spot in forensic science due to their tremendous potential in recent years. In the present study, we investigated 30 indel loci in a Chinese Yi ethnic group. The allele frequencies of the short allele of the 30 indel loci were in the range of 0.1025–0.9221. The power of discrimination values were observed ranging from to 0.2630 (HLD111 locus) to 0.6607 (HLD70 locus) and probability of exclusion values ranged from 0.0189 (HLD111 locus) to 0.2343 (HLD56 locus). The combined power of discrimination and power of exclusion for 30 loci in the studied Yi group were 0.99999999995713 and 0.97746, respectively, which showed tremendous potential for forensic personal identification in the Yi group. Moreover, the DA distances, phylogenetic tree, principal component analysis, and cluster analysis showed the Yi group had close genetic relationships with the Tibetan, South Korean, Chinese Han, and She groups.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.201500003