Interaction of 5-HTTLPR and Idiographic Stressors Predicts Prospective Depressive Symptoms Specifically Among Youth in a Multiwave Design

5-HTTLPR, episodic stressors, depressive and anxious symptoms were assessed prospectively (child and parent report) every 3 months over 1 year (5 waves of data) among community youth ages 9 to 15 (n = 220). Lagged hierarchical linear modeling analyses showed 5-HTTLPR interacted with idiographic stre...

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Bibliographic Details
Published in:Journal of clinical child and adolescent psychology 2011-07, Vol.40 (4), p.572-585
Main Authors: Hankin, Benjamin L., Jenness, Jessica, Abela, John R. Z., Smolen, Andrew
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Alleles
Anxiety
Anxiety disorders
Child
Child psychology
Children
Clinical Psychology
Depression
Depression (Psychology)
Depression - etiology
Depression - genetics
Evaluation Methods
Female
Genetic Predisposition to Disease - genetics
Genetic Predisposition to Disease - psychology
Genotype
Grade 3
Grade 6
Grade 9
Humans
Life Change Events
Male
Mental depression
Polymorphism, Genetic - physiology
Prediction
Psychiatric Status Rating Scales
Science Education
Serotonin
Serotonin Plasma Membrane Transport Proteins - genetics
Serotonin Plasma Membrane Transport Proteins - physiology
Sex Factors
Stress
Stress, Psychological - etiology
Stress, Psychological - genetics
Stress, Psychological - psychology
Surveys and Questionnaires
Symptoms
Symptoms (Individual Disorders)
Young people
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Description
Summary:5-HTTLPR, episodic stressors, depressive and anxious symptoms were assessed prospectively (child and parent report) every 3 months over 1 year (5 waves of data) among community youth ages 9 to 15 (n = 220). Lagged hierarchical linear modeling analyses showed 5-HTTLPR interacted with idiographic stressors (increases relative to the child's own average level over time), but not nomothetic stressors (higher stress exposure relative to the sample), to predict prospective elevations in depressive, but not anxious, symptoms. Youth with copies of the S or L G alleles of 5-HTTLPR, who experienced more stressors relative to their typical level, exhibited prospective increases in depressive symptoms over time. These findings suggest that 5-HTTLPR confers susceptibility to depression via stress reactivity.
ISSN:1537-4416
1537-4424
DOI:10.1080/15374416.2011.581613