Pregnancy outcome in patients with sickle cell disease in the UK – a national cohort study comparing sickle cell anaemia (HbSS) with HbSC disease

Summary We describe the findings from a national study of maternal and fetal outcomes of pregnancy in women with sickle cell disease (SCD). Data were collected via the United Kingdom Obstetric Surveillance System between 1 February 2010 and 31 January 2011 from 109 women, of whom 51 (46·8%) had HbSS...

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Bibliographic Details
Published in:British journal of haematology 2015-04, Vol.169 (1), p.129-137
Main Authors: Oteng‐Ntim, Eugene, Ayensah, Benjamin, Knight, Marian, Howard, Jo
Format: Article
Language:English
Subjects:
Acute Pain - epidemiology
Adult
Birth Weight
Epidemiological Monitoring
Female
Fetal Diseases
haemoglobinopathy
Hemoglobin SC Disease
Humans
Incidence
Live Birth
Pregnancy
Pregnancy Complications, Infectious - epidemiology
sickle
United Kingdom
Urinary Tract Infections - epidemiology
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Summary:Summary We describe the findings from a national study of maternal and fetal outcomes of pregnancy in women with sickle cell disease (SCD). Data were collected via the United Kingdom Obstetric Surveillance System between 1 February 2010 and 31 January 2011 from 109 women, of whom 51 (46·8%) had HbSS and 44 (40·4%) had HbSC. Data included antenatal, maternal and fetal outcomes. Comparisons were made between women with HbSS and HbSC. Incidence of complications were acute pain (57%), blood transfusion (26%), urinary tract infection (UTI; 12%) and critical care unit admission (23%) and these were all more common in women with HbSS than HbSC. There was no difference in the incidence of acute chest syndrome, hypertension and venous thromboembolism between HbSS and HbSC. Women with HbSS were more likely to deliver at
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.13270