Nanovacuums: Nanoparticle Uptake and Differential Cellular Migration on a Carpet of Nanoparticles

The behavior of prostate carcinoma (PC3) cells and human dermal fibroblast (HDF) cells when incubated with sedimented Au NPs in vitro is studied. Darkfield microscopy demonstrates that both PC3 and HDF cells can “vacuum” Au NPs from the surface. Mean square displacement and mean cumulative square di...

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Bibliographic Details
Published in:Nano letters 2013-05, Vol.13 (5), p.2295-2302
Main Authors: Yang, Jie An, Phan, Hoa Tri, Vaidya, Shruti, Murphy, Catherine J
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Cell Movement
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Diffusion in nanoscale solids
Diffusion in solids
Exact sciences and technology
Fibroblasts
Fibroblasts - chemistry
Fibroblasts - cytology
Gold - chemistry
Gold - pharmacokinetics
Human behavior
Humans
Materials science
Metal Nanoparticles - chemistry
Microscopy
Migration
Nanocrystalline materials
Nanoparticles
Nanoscale materials and structures: fabrication and characterization
Nanostructure
Physics
Surface charge
Surface Properties
Transport properties of condensed matter (nonelectronic)
Uptakes
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Summary:The behavior of prostate carcinoma (PC3) cells and human dermal fibroblast (HDF) cells when incubated with sedimented Au NPs in vitro is studied. Darkfield microscopy demonstrates that both PC3 and HDF cells can “vacuum” Au NPs from the surface. Mean square displacement and mean cumulative square distance of cells shows that PC3 migration decreases in the presence of Au NPs while for HDF, migration is dependent on the surface charge and shape of Au NPs.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl400972r