Ethanol intake-induced apoptosis in glial cells and axonal disorders in the cerebellar white matter of UChA rats (voluntary ethanol consumers)

Highlights • The UChA rat showed more glial cells immunoreactive for caspase-3 and less for XIAP. • Ethanol consumption affected myelin integrity with an increase in the interaxonal spaces. • The ethanol induced apoptosis in the glial cells and an intense change in the myelin sheath.

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Bibliographic Details
Published in:Tissue & cell 2015-08, Vol.47 (4), p.389-394
Main Authors: Martinez, Marcelo, Sauce, Rafael, Oliveira, Suelen Alves, de Almeida Chuffa, Luiz Gustavo, Stefanini, Maíra Aparecida, Lizarte Neto, Fermino Sanches, Takase, Luiz Fernando, Tirapelli, Luiz Fernando, Martinez, Francisco Eduardo
Format: Article
Language:English
Subjects:
Advanced Basic Science
Alcohol Drinking
Animals
Apoptosis
Apoptosis - drug effects
Axons - drug effects
Axons - pathology
Axons - ultrastructure
Caspase 3 - biosynthesis
Cerebellum
Ethanol - toxicity
Gene Expression Regulation - drug effects
Glial cells
Inhibitor of Apoptosis Proteins - biosynthesis
Microscopy, Electron, Transmission
Neuroglia - drug effects
Neuroglia - pathology
Neuroglia - ultrastructure
Rats
Rats, Wistar
UChA rat
White Matter - drug effects
White Matter - pathology
White Matter - ultrastructure
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Description
Summary:Highlights • The UChA rat showed more glial cells immunoreactive for caspase-3 and less for XIAP. • Ethanol consumption affected myelin integrity with an increase in the interaxonal spaces. • The ethanol induced apoptosis in the glial cells and an intense change in the myelin sheath.
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2015.05.006