Total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease

The first total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease is described by native chemical ligation. Chemical synthesis of azide-labeled proteins would provide useful protein tools for biochemical, biophysical or medical studies.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-10, Vol.51 (78), p.14632-14635
Main Authors: Qi, Yun-Kun, Chang, Hao-Nan, Pan, Kai-Mai, Tian, Chang-Lin, Zheng, Ji-Shen
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Azides - chemical synthesis
Azides - chemistry
Biochemistry
HIV Protease - chemistry
Medical
Molecular Sequence Data
Protease
Proteins
Spectrometry, Mass, Electrospray Ionization
Synthesis (chemistry)
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Description
Summary:The first total chemical synthesis of the site-selective azide-labeled [I66A]HIV-1 protease is described by native chemical ligation. Chemical synthesis of azide-labeled proteins would provide useful protein tools for biochemical, biophysical or medical studies.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc04846j