Nanoparticles Strengthen Intracellular Tension and Retard Cellular Migration

Nanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired...

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Bibliographic Details
Published in:Nano letters 2014-01, Vol.14 (1), p.83-88
Main Authors: Tay, Chor Yong, Cai, Pingqiang, Setyawati, Magdiel I, Fang, Wanru, Tan, Lay Poh, Hong, Catherine H. L, Chen, Xiaodong, Leong, David Tai
Format: Article
Language:English
Subjects:
Adhesive strength
Assembly
Biology
Cell Adhesion - drug effects
Cell Adhesion - physiology
Cell Line
Cell Movement - drug effects
Cell Movement - physiology
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Diffusion in nanoscale solids
Diffusion in solids
Exact sciences and technology
Humans
Hydroxyapatite
Materials science
Materials Testing
Mechanical and acoustical properties of condensed matter
Mechanical properties of nanoscale materials
Migration
Mouth Mucosa - cytology
Mouth Mucosa - drug effects
Mouth Mucosa - physiology
Nanocrystalline materials
Nanoparticles
Nanoparticles - administration & dosage
Nanoscale materials and structures: fabrication and characterization
Nanostructure
Physics
Tensile Strength - physiology
Titanium dioxide
Transport properties of condensed matter (nonelectronic)
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Summary:Nanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is through nanoparticle-mediated massive disruption of the intracellular microtubule assembly, thereby triggering a positive feedback that promoted stronger substrate adhesions thus leading to limited cell motility.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl4032549