Infectious asthma triggers: time to revise the hygiene hypothesis?

The hygiene hypothesis supports an inverse relationship between respiratory infections in early-life and atopic diseases. However, a recent study supports growing evidence that early-life infection and airway microbiome composition can significantly influence asthma inception and exacerbation later...

Full description

Saved in:
Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2015-07, Vol.23 (7), p.389-391
Main Authors: Webley, Wilmore C, Aldridge, Kelly L
Format: Article
Language:English
Subjects:
asthma
Asthma - epidemiology
Humans
hygiene hypothesis
Internal Medicine
microbiome
Microbiota
Nasopharynx - microbiology
Nasopharynx - virology
respiratory infection
Respiratory Tract Infections - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The hygiene hypothesis supports an inverse relationship between respiratory infections in early-life and atopic diseases. However, a recent study supports growing evidence that early-life infection and airway microbiome composition can significantly influence asthma inception and exacerbation later in life. This reignites discussions on infection-mediated asthma phenotypes and potential therapeutics.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2015.05.006