A plasmonic nanosensor with inverse sensitivity for circulating cell-free DNA quantification

A plasmonic nanosensor (using gold nanorods) with inverse sensitivity is presented for circulating cell-free DNA quantification. The inverse sensitivity (i.e. the lower the analyte concentration, the higher the response intensity) is achieved by the unusual DNA concentration-dependent gold nanorod a...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-10, Vol.51 (77), p.14524-14527
Main Authors: Pallares, Roger M, Kong, Say Li, Ru, Tan Hui, Thanh, Nguyên T K, Lu, Yi, Su, Xiaodi
Format: Article
Language:English
Subjects:
Biosensing Techniques
Cell-Free System
Circulating
Deoxyribonucleic acid
DNA - blood
Gold
Inverse
Limit of Detection
Microscopy, Electron, Transmission
Nanoparticles
Nanorods
Nanostructure
Nanotechnology
Plasmonics
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Summary:A plasmonic nanosensor (using gold nanorods) with inverse sensitivity is presented for circulating cell-free DNA quantification. The inverse sensitivity (i.e. the lower the analyte concentration, the higher the response intensity) is achieved by the unusual DNA concentration-dependent gold nanorod aggregation. This assay method can adjust the dynamic range by controlling the concentration of nanoparticles in solution.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05331e